V6CL75 · V6CL75_CAEEL

  • Protein
    E3 ubiquitin-protein ligase
  • Gene
    hecd-1
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    3/5

Function

function

E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.

Catalytic activity

  • S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N6-ubiquitinyl-[acceptor protein]-L-lysine.
    EC:2.3.2.26 (UniProtKB | ENZYME | Rhea)

Pathway

Protein modification; protein ubiquitination.

Features

Showing features for active site.

126132004006008001,0001,2001,4001,6001,8002,0002,2002,4002,600
TypeIDPosition(s)Description
Active site2582Glycyl thioester intermediate

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Molecular Functionmetal ion binding
Molecular Functionubiquitin protein ligase activity
Biological Processprotein ubiquitination
Biological Processubiquitin-dependent protein catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    E3 ubiquitin-protein ligase
  • EC number

Gene names

    • Name
      hecd-1
    • ORF names
      C34D4.14
      , CELE_C34D4.14

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Bristol N2
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Nematoda > Chromadorea > Rhabditida > Rhabditina > Rhabditomorpha > Rhabditoidea > Rhabditidae > Peloderinae > Caenorhabditis

Accessions

  • Primary accession
    V6CL75

Proteomes

Organism-specific databases

PTM/Processing

Proteomic databases

Expression

Gene expression databases

Structure

3D structure databases

Family & Domains

Features

Showing features for region, compositional bias, domain.

TypeIDPosition(s)Description
Region409-457Disordered
Compositional bias442-456Polar residues
Region608-677Disordered
Compositional bias611-677Polar residues
Region1341-1365Disordered
Compositional bias1347-1365Polar residues
Domain1403-1475MIB/HERC2
Region1503-1527Disordered
Compositional bias1506-1527Polar residues
Region1540-1594Disordered
Region1617-1761Disordered
Compositional bias1634-1687Polar residues
Compositional bias1719-1750Acidic residues
Compositional bias1776-1791Polar residues
Region1776-1801Disordered
Domain2205-2613HECT

Sequence similarities

Belongs to the UPL family. K-HECT subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    2,613
  • Mass (Da)
    288,392
  • Last updated
    2014-02-19 v1
  • Checksum
    C870F0B647444453
MDGIDPETLLEWLQTGIGDERDLQLMALEQLCMLLLMADNIDRCFESCPPRTFIPALCKIFIDETAPDNVLEVTARAITYYLDVSNECTRRITQVDGAVKAICTRLAAADISDRSSKDLAEQCVKLLEHVCQRETMAVYDAGGINAMLTLVRVHGTQVHKDTMHSAMSVVTRLCGKMEPTDPELGKCAESLGALLEHEDPKVSESALRCFAALTDRFVRKMMDPAELAMHSNLVEHLISIMVASNDENSPTTASANILSIVLSLIGNLCRGSSLITEKVLTSPNMITGLKATLTNKEERVVTDGLRFCDLLLVLLCEGRSALPLTSVVSGDYAAGSGAERVHRQLIDAIRQKDLTALVDAIESGQVDVNFADDVGQSLTNWASAFGSIEMRGANPDLRDEDGKTALDKARERSDDDHNQVANILESPSAFMRNKEDPKVKASTSKQPGTSTKPELPNPNLVRKVLHQLLPIFCEIFQKSLNGSVRRTSLSLMRKIVENIGDLRQSAVGDGNAPAAQSARKMSTDVSAGAESLVAVVVSVMDQEDDHEGHEQVLLILESLLEKDAELWVIELVRLGVFERVEAMAKEPPKGLEEVLNAIHLEGRSRVTPMEIDFENQPSSSTAVPTANDIMDTTVPSSSGGADAESNSNPSTIEMADPESSTPSSSTQQSISKPKATASSTASSAILQVVSKLSSVASLDKSAAAVDKKPTKTVLSQGTPYRWKEWRIVRGTTSLFIWSDVLLIELPFQSNGWFRYLADNDSHVQFVTGTASVDQQMTEEEKDNFQKTERREMVSRWNAVKGVFDDDWSSVPIAVLGIPSNAKKVSQKLEVPAWELWSSKSSELQIKSISSSAPTGQANTMLTTIKIQDDAGGFLFETGTGRKTNVMPEHALPSDFHTGWSSHGVSTRKMKFRQDIQKRKVQELAWKLWNDHLKEAHAKPREALVRLENAARTIESTIRHVKAQSNFKHRNVKQPRIERVQEYCAAISTLHESIVDDRRLSTFEFSVSGIVPALFGLLSMMEKFPDSFPSRIFKEQFSKGEALSYLALKIVAVLEANEKFPQHLYDSPGGSSFGLQLLSRRVRTKLEMLPRADGKENNDENLVNKTGKIVKCEPLASVGAIRAYLHRMVTRQWHDRERANYRYVKEIQELKTKGKSIELRHVSDFDENGVIYWIGTNGRAAPLWTNPATVKAVKITCSDTRQPFGKPEDLLSRDQNPINCHTSDDKNAHFTIDLGLFVVPTSYSLRHSRGYGRSALRNWMLQGSVDAKRWENVIVHTDDKGLGEPGSTATWHVGEKGTTAFRFFRIAQNGKNSSGQTHYLSCSGFEIYGDIVDVVTEAICEDPPKKDSPAGTSSTPGSSSSAALPPLTKEQVLEMLPARENNNRLKSGLSLETVTSMLQRSRHRSRGSYKISESKSKVVRGKDWRWEDQDGGEGKFGRITSPPESGWVDVTWDNGNANSYRFGANGNFDIERVTSTGHRYSTPSLASHVPTSVMEAVRRNRAFYTPKTTGGPPSSSVFGTSSSAGSSRGAASALSRFASVKNTTPAGTPSSGGSSGGAIGKKSMSTTNLVDERQKTSGPSVASTGQAASAESLQHQTPSLENLLARAMPHAFGRIAENQEPEDEPMGGEESDSAASMRSAASSNSQMSMGSSSQQQQQQDSDMTPRDSAGTPSTPRDDKNQTLSVSAPDLAAARQRQASAETDGDADADETNSEDKTVGADDAMEEDDEEEETMEDEEDDDDDDDDESSNENQEKLVELLGGERGLFDKLKEVITGESLSDASSSAKDATTNEAQKKGGKKPKKWFKKMSSYTDVLKGLMQNRYPVALLDPAAAGIEMDEMMDDDDYYDFSEDGPDDGDSVEDEVAAHLGMPVDSFASMVAARTPITWRQFSELMSGSNRERAAMARAVASSRGSPWEDDATVKCTFEALIPAFDPRPGRSNVNQTLEVELPTVVKDFGSTKASSSKIDKDDQMRFFLRGPNMSGVDNVTIEMNDDSASLFRYMQIINNSVNWATKSDRSRRIWEPTYSICYCSADQTNVEVSKIPDEESSTPCQVNQCLETIGLLSRIQQAMPEAEITPNVFISDKLTLKVTQVLSDALVVAARSLPEWCSRLVYKYPCLFTVETRNMYMQATAFGVSRTIVWLQQRRDAAVERARGSAQAGNSSAARQHDRYHEYRVGRLRHERVKVTRAEETLLDQAIRLMKFHADRKAVLEIEYTNEEGTGLGPTLEFYALVAAELQRKSLALWVCDDDDTHASKSGEEREVDLGEGKKPIGYYVRRVGGLFPAPLPPGTDETKRAADMFRVLGVFLAKVLLDGRLVDLPLSRPFLKLLVHPQIGDDARGPNLHKILSLDDFEEVNPVKGSFLKELRALAQRKRLIENDTSIDSNSKRRKIAELKLHIKGSTCRVEDLALNFTVNPPSKVFQYAEMELVDGGSDIDVTIDNVEQYVEKCEEFYLNTGIAYQMRAFRDGFDRVFPLRTLRAYSPEEVQRLLSGEQCPEWSRDDILNYTEPKLGYTRESPGFLRFVDVMEALTAQERKNFLQFATGCSSLPPGGLANLHPRLTIVRKVESGDGSYPSVNTCVHYLKLPEYSSSAILRERLLTAINEKGFHLN

Computationally mapped potential isoform sequences

There are 7 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
V6CLA2HECD1_CAEELhecd-12648
V6CLA7V6CLA7_CAEELhecd-12650
V6CLC0V6CLC0_CAEELhecd-12646
V6CJX7V6CJX7_CAEELhecd-12644
V6CL74V6CL74_CAEELhecd-12611
V6CIS4V6CIS4_CAEELhecd-12607
V6CIS8V6CIS8_CAEELhecd-12609

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias442-456Polar residues
Compositional bias611-677Polar residues
Compositional bias1347-1365Polar residues
Compositional bias1506-1527Polar residues
Compositional bias1634-1687Polar residues
Compositional bias1719-1750Acidic residues
Compositional bias1776-1791Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BX284604
EMBL· GenBank· DDBJ
CDK13345.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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