V5W4C2 · V5W4C2_9APIC

  • Protein
    Cytochrome c oxidase subunit 1
  • Gene
    COX1
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Pathway

Energy metabolism; oxidative phosphorylation.

GO annotations

AspectTerm
Cellular Componentmitochondrial respiratory chain complex IV
Molecular Functioncytochrome-c oxidase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processelectron transport coupled proton transport
Biological Processmitochondrial electron transport, cytochrome c to oxygen

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 1
  • EC number

Gene names

    • Name
      COX1
    • Synonyms
      cox1

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • Vl2.1
    • Vl2.2
    • Ll67
    • Mf1
    • Mf41
  • Taxonomic lineage
    Eukaryota > Sar > Alveolata > Apicomplexa > Conoidasida > Coccidia > Eucoccidiorida > Eimeriorina > Sarcocystidae > Sarcocystis

Accessions

  • Primary accession
    V5W4C2

Subcellular Location

Membrane
; Multi-pass membrane protein
Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane6-23Helical
Transmembrane58-76Helical
Transmembrane88-106Helical
Transmembrane135-161Helical
Transmembrane173-199Helical
Transmembrane219-243Helical
Transmembrane255-279Helical
Transmembrane291-313Helical
Transmembrane325-347Helical

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-351Cytochrome oxidase subunit I profile

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    351
  • Mass (Da)
    38,185
  • Last updated
    2014-02-19 v1
  • Checksum
    3B6843AC6B276A50
IAGMYIITGAIFSVVGTLMSNMIRVELSSTGSRIICVETISTYNVIITLHGLSMIFMFLMPALFAGFGNYFVPIYIGSSEVVYPRINAVSYFLVPLGSILVMQSIISEYGSGMGWTMYPPLSSSLMTLNTESVDWIIIGLAVLGISSVLGSINFLGTSLFLGSVSGCRPNILYIWAIIFTAIMLIVTLPILTGGLVMLLMDLHTNSEFYDSMYSGDSVLYQHLFWFFGHPEVYILILPGFGVISQTLSTYATRSVFGGQSMILAMGCIAILGSLVWAHHMMTVGLEVDTRAYFSAVTIMIAIPTGTKIFNWLGTYMANNNVTRQVDLWCALSFIILFTLGGTTGVVMGNAS

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue351

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KF601326
EMBL· GenBank· DDBJ
AHC00603.1
EMBL· GenBank· DDBJ
Genomic DNA
KF601327
EMBL· GenBank· DDBJ
AHC00604.1
EMBL· GenBank· DDBJ
Genomic DNA
MF596284
EMBL· GenBank· DDBJ
AVL27399.1
EMBL· GenBank· DDBJ
Genomic DNA
MF596285
EMBL· GenBank· DDBJ
AVL27400.1
EMBL· GenBank· DDBJ
Genomic DNA
MG273661
EMBL· GenBank· DDBJ
AWH12483.1
EMBL· GenBank· DDBJ
Genomic DNA
MG273662
EMBL· GenBank· DDBJ
AWH12484.1
EMBL· GenBank· DDBJ
Genomic DNA
MG273663
EMBL· GenBank· DDBJ
AWH12485.1
EMBL· GenBank· DDBJ
Genomic DNA
MG273664
EMBL· GenBank· DDBJ
AWH12486.1
EMBL· GenBank· DDBJ
Genomic DNA
MG273665
EMBL· GenBank· DDBJ
AWH12487.1
EMBL· GenBank· DDBJ
Genomic DNA
MG273666
EMBL· GenBank· DDBJ
AWH12488.1
EMBL· GenBank· DDBJ
Genomic DNA
MG273667
EMBL· GenBank· DDBJ
AWH12489.1
EMBL· GenBank· DDBJ
Genomic DNA
MG273668
EMBL· GenBank· DDBJ
AWH12490.1
EMBL· GenBank· DDBJ
Genomic DNA
MG273669
EMBL· GenBank· DDBJ
AWH12491.1
EMBL· GenBank· DDBJ
Genomic DNA
MG273670
EMBL· GenBank· DDBJ
AWH12492.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp