V5VFS9 · V5VFS9_ACIBA
- ProteinLon protease
- Genelon
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids809 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
function
ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.
Catalytic activity
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 369-376 | ATP (UniProtKB | ChEBI) | |||
Active site | 693 | ||||
Active site | 736 | ||||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | ATP binding | |
Molecular Function | ATP hydrolysis activity | |
Molecular Function | ATP-dependent peptidase activity | |
Molecular Function | sequence-specific DNA binding | |
Molecular Function | serine-type endopeptidase activity | |
Biological Process | cellular response to heat | |
Biological Process | protein quality control for misfolded or incompletely synthesized proteins |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameLon protease
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Moraxellales > Moraxellaceae > Acinetobacter > Acinetobacter calcoaceticus/baumannii complex
Accessions
- Primary accessionV5VFS9
- Secondary accessions
Proteomes
Subcellular Location
Expression
Induction
By heat shock.
Interaction
Subunit
Homohexamer. Organized in a ring with a central cavity.
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 20-216 | Lon N-terminal | |||
Domain | 606-787 | Lon proteolytic | |||
Sequence similarities
Belongs to the peptidase S16 family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length809
- Mass (Da)90,128
- Last updated2014-02-19 v1
- MD5 ChecksumDE6F3CDA393F9E28D421EBC389DD79F9
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP008706 EMBL· GenBank· DDBJ | AKA32579.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP018664 EMBL· GenBank· DDBJ | APP31561.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AAYLMQ010000051 EMBL· GenBank· DDBJ | EGY2378833.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LLGC01000164 EMBL· GenBank· DDBJ | KQE04778.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LRDT01000013 EMBL· GenBank· DDBJ | KZA20263.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JACSVK010000041 EMBL· GenBank· DDBJ | MBD0221109.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JACZEI010000004 EMBL· GenBank· DDBJ | MBE0329875.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JARTMM010000009 EMBL· GenBank· DDBJ | MDK4880915.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JARTMM020000001 EMBL· GenBank· DDBJ | MEC5495979.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
WIOC01000005 EMBL· GenBank· DDBJ | MQR48833.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
VYTH01000004 EMBL· GenBank· DDBJ | MQZ67760.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
WPIP01000071 EMBL· GenBank· DDBJ | MVM92048.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
WWCH01000001 EMBL· GenBank· DDBJ | MYM77424.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JAAGTY010000008 EMBL· GenBank· DDBJ | NDW41123.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
NGEL01000141 EMBL· GenBank· DDBJ | OTM84490.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
NGKM01000005 EMBL· GenBank· DDBJ | OWK67150.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
NXDV01000008 EMBL· GenBank· DDBJ | PHQ02600.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
NEPB01000037 EMBL· GenBank· DDBJ | PRN32712.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
QKWF01000164 EMBL· GenBank· DDBJ | PZM14443.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP061525 EMBL· GenBank· DDBJ | QNV20880.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP059300 EMBL· GenBank· DDBJ | QOJ61939.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP062919 EMBL· GenBank· DDBJ | QPF14297.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP072270 EMBL· GenBank· DDBJ | QTK42581.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
RFBY01000003 EMBL· GenBank· DDBJ | RSP81096.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
RXLU01000121 EMBL· GenBank· DDBJ | RTQ69610.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
RXYO01000055 EMBL· GenBank· DDBJ | RTY06104.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
UFDJ01000015 EMBL· GenBank· DDBJ | SSI56733.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
UFMQ01000002 EMBL· GenBank· DDBJ | SST18397.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
UFNM01000003 EMBL· GenBank· DDBJ | SST99830.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
VHEY01000023 EMBL· GenBank· DDBJ | TPS86750.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
VHGY01000007 EMBL· GenBank· DDBJ | TPU68605.1 EMBL· GenBank· DDBJ | Genomic DNA |