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V5VFS9 · V5VFS9_ACIBA

Function

function

ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.

Catalytic activity

  • Hydrolysis of proteins in presence of ATP.
    EC:3.4.21.53 (UniProtKB | ENZYME | Rhea)

Features

Showing features for binding site, active site.

1809100200300400500600700800
Type
IDPosition(s)Description
Binding site369-376ATP (UniProtKB | ChEBI)
Active site693
Active site736

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Molecular FunctionATP-dependent peptidase activity
Molecular Functionsequence-specific DNA binding
Molecular Functionserine-type endopeptidase activity
Biological Processcellular response to heat
Biological Processprotein quality control for misfolded or incompletely synthesized proteins

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Lon protease
  • EC number
  • Alternative names
    • ATP-dependent protease La

Gene names

    • Name
      lon
    • ORF names
      ABUW_2865
      , APD33_10235
      , AUO97_12370
      , B9W25_14345
      , B9X95_12435
      , CBE85_06865
      , CPI82_12120
      , DOL94_14415
      , EA722_02000
      , EJ062_17360
      , EKS29_18145
      , F2P40_05740
      , F4T85_05070
      , FJU42_01815
      , FJU79_07995
      , FQZ18_14105
      , G3N53_08540
      , GNY86_11005
      , GSE42_05690
      , H0529_10070
      , IAG11_14525
      , IHV20_06870
      , IMO23_05065
      , J6E47_14340
      , JHZ39_003254
      , LV35_01159
      , P9867_005340
      , P9867_04065
      , SAMEA104305318_00771
      , SAMEA104305340_00892
      , SAMEA4394745_02694

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • ATCC 17978
    • AB5075-UW
    • ABBL072
    • AB2828
    • DMS06669
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Moraxellales > Moraxellaceae > Acinetobacter > Acinetobacter calcoaceticus/baumannii complex

Accessions

  • Primary accession
    V5VFS9
  • Secondary accessions
    • B0V9Q2

Proteomes

Subcellular Location

Keywords

Expression

Induction

By heat shock.

Interaction

Subunit

Homohexamer. Organized in a ring with a central cavity.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain20-216Lon N-terminal
Domain606-787Lon proteolytic

Sequence similarities

Belongs to the peptidase S16 family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    809
  • Mass (Da)
    90,128
  • Last updated
    2014-02-19 v1
  • MD5 Checksum
    DE6F3CDA393F9E28D421EBC389DD79F9
MSELIMNEKTDLEPQVPSVLPLLALRDVVVYPHMQIALFVGREKSINAVDVARNSDNLVFVVAQKDSLTEEIDHDNLYQYGTVAKIVQVVNHENDENCIKVLIEGLHRSKLKKIIDEDSYLTAEHELSPMTINVDKATQETRLQELRNLFAQYAEAKLRNARELVAAANKIEDLLQLMFFVATRVPLNIEIKQKFLEYDEFEAHLQELMNYLMNQSAEQQIEQTLHDSVKRQMEKNQREYFLNEKMKVIQRELSDMNGGAEDDVAEIEKRLAEADLPEHVRKKAEAEFRKLKAMQPASSEAAVVRNYLEVILDTPWNKASKVSINLNKAQEILDADHYGLDDVKDRIVEYLAVQSRVKKLKGPILCLVGPPGVGKTSLGESVAKATGREFVRMALGGVRDEAEIRGHRRTYIGAMPGKIVQSLTKVGVKNPLFLLDEIDKMAQDYRGDPASALLEVLDPSQNSKFNDHYLDLDLDLSEVMFICTANSMNIPEALLDRMEVIRLPGYTEDEKVNIAERYLVPKAIKNNGLRPKELTIHEEAIRDIVQRYTREAGVRNLEREVSKIARKVVKEAVSKKSKNLQLDVTSANLPEYLGPHKFDFGMAEDEAQVGRVNGLAWTSVGGELLTIEVAAVKGKGKFITTGSLGDVMKESITTAMTVVRTRADELGIEASRFEETDVHVHLPEGATPKDGPSAGLALTTALVSAFTGIAIRPDIAMTGETSLGGRAMRIGGLKEKLLAAHRGGIKLVFIPQDNVRDLAEIPDNVKEGLEIKAVKSIDEILPLALTSMPKPLPKTPIVKPVEGSKAARH

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP008706
EMBL· GenBank· DDBJ
AKA32579.1
EMBL· GenBank· DDBJ
Genomic DNA
CP018664
EMBL· GenBank· DDBJ
APP31561.1
EMBL· GenBank· DDBJ
Genomic DNA
AAYLMQ010000051
EMBL· GenBank· DDBJ
EGY2378833.1
EMBL· GenBank· DDBJ
Genomic DNA
LLGC01000164
EMBL· GenBank· DDBJ
KQE04778.1
EMBL· GenBank· DDBJ
Genomic DNA
LRDT01000013
EMBL· GenBank· DDBJ
KZA20263.1
EMBL· GenBank· DDBJ
Genomic DNA
JACSVK010000041
EMBL· GenBank· DDBJ
MBD0221109.1
EMBL· GenBank· DDBJ
Genomic DNA
JACZEI010000004
EMBL· GenBank· DDBJ
MBE0329875.1
EMBL· GenBank· DDBJ
Genomic DNA
JARTMM010000009
EMBL· GenBank· DDBJ
MDK4880915.1
EMBL· GenBank· DDBJ
Genomic DNA
JARTMM020000001
EMBL· GenBank· DDBJ
MEC5495979.1
EMBL· GenBank· DDBJ
Genomic DNA
WIOC01000005
EMBL· GenBank· DDBJ
MQR48833.1
EMBL· GenBank· DDBJ
Genomic DNA
VYTH01000004
EMBL· GenBank· DDBJ
MQZ67760.1
EMBL· GenBank· DDBJ
Genomic DNA
WPIP01000071
EMBL· GenBank· DDBJ
MVM92048.1
EMBL· GenBank· DDBJ
Genomic DNA
WWCH01000001
EMBL· GenBank· DDBJ
MYM77424.1
EMBL· GenBank· DDBJ
Genomic DNA
JAAGTY010000008
EMBL· GenBank· DDBJ
NDW41123.1
EMBL· GenBank· DDBJ
Genomic DNA
NGEL01000141
EMBL· GenBank· DDBJ
OTM84490.1
EMBL· GenBank· DDBJ
Genomic DNA
NGKM01000005
EMBL· GenBank· DDBJ
OWK67150.1
EMBL· GenBank· DDBJ
Genomic DNA
NXDV01000008
EMBL· GenBank· DDBJ
PHQ02600.1
EMBL· GenBank· DDBJ
Genomic DNA
NEPB01000037
EMBL· GenBank· DDBJ
PRN32712.1
EMBL· GenBank· DDBJ
Genomic DNA
QKWF01000164
EMBL· GenBank· DDBJ
PZM14443.1
EMBL· GenBank· DDBJ
Genomic DNA
CP061525
EMBL· GenBank· DDBJ
QNV20880.1
EMBL· GenBank· DDBJ
Genomic DNA
CP059300
EMBL· GenBank· DDBJ
QOJ61939.1
EMBL· GenBank· DDBJ
Genomic DNA
CP062919
EMBL· GenBank· DDBJ
QPF14297.1
EMBL· GenBank· DDBJ
Genomic DNA
CP072270
EMBL· GenBank· DDBJ
QTK42581.1
EMBL· GenBank· DDBJ
Genomic DNA
RFBY01000003
EMBL· GenBank· DDBJ
RSP81096.1
EMBL· GenBank· DDBJ
Genomic DNA
RXLU01000121
EMBL· GenBank· DDBJ
RTQ69610.1
EMBL· GenBank· DDBJ
Genomic DNA
RXYO01000055
EMBL· GenBank· DDBJ
RTY06104.1
EMBL· GenBank· DDBJ
Genomic DNA
UFDJ01000015
EMBL· GenBank· DDBJ
SSI56733.1
EMBL· GenBank· DDBJ
Genomic DNA
UFMQ01000002
EMBL· GenBank· DDBJ
SST18397.1
EMBL· GenBank· DDBJ
Genomic DNA
UFNM01000003
EMBL· GenBank· DDBJ
SST99830.1
EMBL· GenBank· DDBJ
Genomic DNA
VHEY01000023
EMBL· GenBank· DDBJ
TPS86750.1
EMBL· GenBank· DDBJ
Genomic DNA
VHGY01000007
EMBL· GenBank· DDBJ
TPU68605.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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