V5TTE9 · V5TTE9_9ENTR

  • Protein
    Bifunctional aspartokinase/homoserine dehydrogenase
  • Gene
    metL
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Bifunctional aspartate kinase and homoserine dehydrogenase that catalyzes the first and the third steps toward the synthesis of lysine, methionine and threonine from aspartate.

Catalytic activity

Cofactor

a metal cation (UniProtKB | Rhea| CHEBI:25213 )

Pathway

Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 1/4.
Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 1/3.
Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 3/3.
Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 1/5.
Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 3/5.

GO annotations

AspectTerm
Molecular Functionaspartate kinase activity
Molecular FunctionATP binding
Molecular Functionhomoserine dehydrogenase activity
Molecular FunctionNADP binding
Biological Processlysine biosynthetic process via diaminopimelate
Biological Processthreonine biosynthetic process

Keywords

Enzyme and pathway databases

    • UPA00034UER00015
    • UPA00050UER00063
    • UPA00051UER00462

Names & Taxonomy

Protein names

  • Recommended name
    Bifunctional aspartokinase/homoserine dehydrogenase

Including 2 domains:

  • Recommended name
    Aspartokinase
  • EC number
  • Recommended name
    Homoserine dehydrogenase
  • EC number

Gene names

    • Name
      metL
    • Synonyms
      metM
    • ORF names
      C3E80_13215
      , P262_00209

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • 45402
    • CMCC45402
    • S1
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Enterobacteriaceae > Cronobacter

Accessions

  • Primary accession
    V5TTE9

Proteomes

Interaction

Subunit

Homotetramer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain12-284Aspartate/glutamate/uridylate kinase
Domain465-600Aspartate/homoserine dehydrogenase NAD-binding
Domain608-803Homoserine dehydrogenase catalytic

Sequence similarities

In the C-terminal section; belongs to the homoserine dehydrogenase family.
In the N-terminal section; belongs to the aspartokinase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    810
  • Mass (Da)
    88,874
  • Last updated
    2014-02-19 v1
  • Checksum
    5137446C90A932AC
MSVTAPAGTNGRQLHKFGGSSLADVKCYLRVAGIMADYSRAGDMMVVSAAGSTTNQLISWLKLSQSDRLSAHQVQQALRRYQSELISGLLPAAVADGLISEFIHDLERLAALLDGTITDAVYAEVVGHGEIWSARLMAAVLNHQGIDAAWLDARDFLRAERAAQPQVNEGLSFPLLQQLLVQHPNKRLVVTGFICRNDAGETVLLGRNGSDYSATQIGALAGVSRVTIWSDVAGVYSADPRKVKDACLLPLLRLDEASELARLAAPVLHARTLQPVSGSDIDLQLRCSYSPEQGSTRIERVLASGTGARIVTSHDDVCLIEFEVPSHQDFKLAHKEVDALLRRAQLRPLSVGVHPDRRLLQLCYTSEVVGSALKLLEDAALPGELRLREGLALVALVGAGVCRNPLHSHRFWQQLKDQPVEFIWQSEEAISLVAVLRTGPTESLIQGLHQSLFRAEKRIGLMLFGKGNIGSRWLELFAREQETLSARTGLEFVLAGVVDSRRSLLNYDGLDASRALAFFNDEAVEQDEESLFLWMRAHPYDDLVVLDVTASQDLADQYLDFASYGFHVISANKLAGASNSQNYRQIRDAFAKTGRHWLYNATVGAGLPVNHTVRDLRDSGDSILSISGIFSGTLSWLFLQFDGTVPFTELVDQAWQQGLTEPDPRVDLSGKDVMRKLVILAREAGYDIEPDQVRVESLVPAGCEEGSVDHFFEYGDALNEQMVQRLEAARELGLVLRYVARFDANGKARVGVEAVRPEHPLASLLPCDNVFAIESRWYRDNPLVIRGPGAGRDVTAGAIQSDLNRLAQLL

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP006731
EMBL· GenBank· DDBJ
AHB68506.1
EMBL· GenBank· DDBJ
Genomic DNA
PQJL01000014
EMBL· GenBank· DDBJ
ROW60604.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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