V5NBV4 · TPM_MACRS

Function

function

Tropomyosin, in association with the troponin complex, plays a central role in the calcium dependent regulation of muscle contraction.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentactin filament
Molecular Functionactin filament binding
Molecular Functionprotein homodimerization activity
Biological Processactin filament organization
Biological Processlocomotion
Biological Processmuscle contraction
Biological Processmuscle system process
Biological Processregulation of muscle contraction

Keywords

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Tropomyosin Mac r 1.0101
  • Alternative names
    • Major allergen Mac r 1.0101
  • Allergen name
    Mac r 1.0101

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Crustacea > Multicrustacea > Malacostraca > Eumalacostraca > Eucarida > Decapoda > Pleocyemata > Caridea > Palaemonoidea > Palaemonidae > Macrobrachium

Accessions

  • Primary accession
    V5NBV4
  • Secondary accessions
    • D3XNR9

Subcellular Location

Phenotypes & Variants

Allergenic properties

Causes an allergic reaction in human. Natural protein binds to IgE in patients allergic to giant fresh water prawn (M.rosenbergii) (PubMed:23569834, PubMed:27001653, PubMed:34255496).
Recombinant protein binds to IgE in 77% of the 13 Thai children tested allergic to both seawater prawn P.monodon and freshwater prawn M.rosenbergii. Cross-reacts with P.monodon tropomyosin allergen Pen m 1 (PubMed:27001653).
Cross-reacts with tropomyosins of freshwater crustaceans M.lanchesteri, C.quadricarinatus and P.clarkii (PubMed:34255496).

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variant44-45

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 1 variant from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Keywords

Protein family/group databases

PTM/Processing

Features

Showing features for modified residue, chain.

TypeIDPosition(s)Description
Modified residue1N-acetylmethionine
ChainPRO_00004556971-284Tropomyosin Mac r 1.0101

Keywords

Expression

Tissue specificity

Expressed in muscle (at protein level) (PubMed:34255496).
Expressed in abdominal muscle (PubMed:27001653).

Interaction

Subunit

Homodimer.

Structure

Family & Domains

Features

Showing features for region, coiled coil.

TypeIDPosition(s)Description
Region1-42Disordered
Coiled coil1-273

Domain

The molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The sequence exhibits a prominent seven-residues periodicity.

Sequence similarities

Belongs to the tropomyosin family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    284
  • Mass (Da)
    32,829
  • Last updated
    2014-02-19 v1
  • Checksum
    8ACA4C565D73B144
MDAIKKKMQAMKLEKDNAMDRADTLEQQNKEANNRAEKSEEEVFSLQKRMQQLENDLDSVQEALLKANQHLEEKDKALSNAEGEVAALNRRIQLLEEDLERSEERLNTATTKLAEASQAADESERMRKVLENRSLSDEERMDALENQLKEARFLAEEADRKYDEVARKLAMVEADLERAEERAETGESKIVELEEELRVVGNNLKSLEVSEEKANQREEAYKEQIKTLTNKLKAAEARAEFAERSVQKLQKEVDRLEDELVNEKEKYKSITDELDQTFSELSGY

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KF571722
EMBL· GenBank· DDBJ
AHA85706.1
EMBL· GenBank· DDBJ
mRNA
GU369816
EMBL· GenBank· DDBJ
ADC55380.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

Disclaimer

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