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V5A4T7 · V5A4T7_9ARCH

Function

function

Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Cofactor

pyridoxal 5'-phosphate (UniProtKB | Rhea| CHEBI:597326 )

Pathway

Amino-acid biosynthesis; glycine biosynthesis; glycine from L-serine: step 1/1.

Features

Showing features for binding site, site.

150150100150200250300350400450500
Type
IDPosition(s)Description
Binding site206(6S)-5,6,7,8-tetrahydrofolate (UniProtKB | ChEBI)
Binding site210-212(6S)-5,6,7,8-tetrahydrofolate (UniProtKB | ChEBI)
Site314Plays an important role in substrate specificity
Binding site440-442(6S)-5,6,7,8-tetrahydrofolate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functioncobalt ion binding
Molecular Functionglycine hydroxymethyltransferase activity
Molecular Functionmethyltransferase activity
Molecular Functionpyridoxal phosphate binding
Molecular Functionserine binding
Molecular Functionzinc ion binding
Biological Processfolic acid metabolic process
Biological Processglycine biosynthetic process from serine
Biological ProcessL-serine catabolic process
Biological Processmethylation
Biological Processtetrahydrofolate interconversion

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Serine hydroxymethyltransferase
  • EC number
  • Short names
    SHMT
    ; Serine methylase

Gene names

    • Name
      glyA
    • ORF names
      A07HR60_02550

Organism names

Accessions

  • Primary accession
    V5A4T7

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for modified residue.

TypeIDPosition(s)Description
Modified residue315N6-(pyridoxal phosphate)lysine

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for region, compositional bias, domain.

Type
IDPosition(s)Description
Region1-28Disordered
Compositional bias9-23Basic and acidic residues
Domain94-471Serine hydroxymethyltransferase-like

Sequence similarities

Belongs to the SHMT family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    501
  • Mass (Da)
    54,206
  • Last updated
    2014-01-22 v1
  • MD5 Checksum
    3A030E6D3DE9E98C2FD28631D2BB2F11
MSNGHETDLFTAEPHRIRPSRLSRETGETGQIDWQIPGDFCASRGQSCDLADLQAPLAQFCQLCWALSWVKPATTDRLYLGGASLRSMNHDSVRDVDPEVANALEAEVDRQRDTLAMIASENHASPAVISAQGSALTNKYAEGYPGERYYAGCEHADEVESLAIERAKKLWGAEHVNVQPHSGTQANQAVYGSVLEPGDKILSLDLNHGGHLSHGHKANFAGQLYEVEQYHVDPETGYLDYEGLADMADSFNPDMIVSGYSAYPREVEWERIQKAADATDAYHLSDIAHITGLVAAGVHSSPVGVADFVTGSTHKTVRAGRGGIIMCQDQYADKIDAAVFPGGQGGPLMHNIAGKAVGFKEALQPEFVTYAEQVIENAEELAATFRDHGFSLVSGGTDNHLVLVDLRDSHPDLSGGRAEESLAAADIVLNGNTVPGETRSPFDPSGIRAGTAALTTRGFDTDAIREVGDLIYRVVDNYDDDAVISDVRDRVDMLTDEYTLY

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias9-23Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KI543234
EMBL· GenBank· DDBJ
ESS10535.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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