V5A4T7 · V5A4T7_9ARCH
- ProteinSerine hydroxymethyltransferase
- GeneglyA
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids501 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
Cofactor
Pathway
Amino-acid biosynthesis; glycine biosynthesis; glycine from L-serine: step 1/1.
Features
Showing features for binding site, site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 206 | (6S)-5,6,7,8-tetrahydrofolate (UniProtKB | ChEBI) | |||
Binding site | 210-212 | (6S)-5,6,7,8-tetrahydrofolate (UniProtKB | ChEBI) | |||
Site | 314 | Plays an important role in substrate specificity | |||
Binding site | 440-442 | (6S)-5,6,7,8-tetrahydrofolate (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | cobalt ion binding | |
Molecular Function | glycine hydroxymethyltransferase activity | |
Molecular Function | methyltransferase activity | |
Molecular Function | pyridoxal phosphate binding | |
Molecular Function | serine binding | |
Molecular Function | zinc ion binding | |
Biological Process | folic acid metabolic process | |
Biological Process | glycine biosynthetic process from serine | |
Biological Process | L-serine catabolic process | |
Biological Process | methylation | |
Biological Process | tetrahydrofolate interconversion |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameSerine hydroxymethyltransferase
- EC number
- Short namesSHMT ; Serine methylase
Gene names
Organism names
- Organism
- Taxonomic lineageArchaea > environmental samples
Accessions
- Primary accessionV5A4T7
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for modified residue.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Modified residue | 315 | N6-(pyridoxal phosphate)lysine | |||
Interaction
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 1-28 | Disordered | |||
Compositional bias | 9-23 | Basic and acidic residues | |||
Domain | 94-471 | Serine hydroxymethyltransferase-like | |||
Sequence similarities
Belongs to the SHMT family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length501
- Mass (Da)54,206
- Last updated2014-01-22 v1
- MD5 Checksum3A030E6D3DE9E98C2FD28631D2BB2F11
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 9-23 | Basic and acidic residues | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
KI543234 EMBL· GenBank· DDBJ | ESS10535.1 EMBL· GenBank· DDBJ | Genomic DNA |