V4YSC8 · V4YSC8_9PROT
- ProteinDNA topoisomerase 4 subunit B
- GeneparE
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids667 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.
Catalytic activity
Cofactor
Features
Showing features for binding site, site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 20 | ATP (UniProtKB | ChEBI) | |||
Binding site | 57 | ATP (UniProtKB | ChEBI) | |||
Binding site | 84 | ATP (UniProtKB | ChEBI) | |||
Binding site | 128-134 | ATP (UniProtKB | ChEBI) | |||
Binding site | 358 | ATP (UniProtKB | ChEBI) | |||
Site | 470 | Interaction with DNA | |||
Site | 525 | Interaction with DNA | |||
Site | 652 | Interaction with DNA | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | chromosome | |
Molecular Function | ATP binding | |
Molecular Function | DNA binding | |
Molecular Function | DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity | |
Biological Process | chromosome segregation | |
Biological Process | DNA topological change |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameDNA topoisomerase 4 subunit B
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Betaproteobacteria
Accessions
- Primary accessionV4YSC8
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Interaction
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 436-553 | Toprim | |||
Sequence similarities
Belongs to the type II topoisomerase GyrB family.
Belongs to the type II topoisomerase family. ParE type 1 subfamily.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length667
- Mass (Da)73,186
- Last updated2014-01-22 v1
- ChecksumBE4837F89A3AD5DA
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AYMW01000001 EMBL· GenBank· DDBJ | ESS14577.1 EMBL· GenBank· DDBJ | Genomic DNA |