V4YSC8 · V4YSC8_9PROT

Function

function

Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

  • ATP-dependent breakage, passage and rejoining of double-stranded DNA.
    EC:5.6.2.2 (UniProtKB | ENZYME | Rhea)

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Features

Showing features for binding site, site.

166750100150200250300350400450500550600650
Type
IDPosition(s)Description
Binding site20ATP (UniProtKB | ChEBI)
Binding site57ATP (UniProtKB | ChEBI)
Binding site84ATP (UniProtKB | ChEBI)
Binding site128-134ATP (UniProtKB | ChEBI)
Binding site358ATP (UniProtKB | ChEBI)
Site470Interaction with DNA
Site525Interaction with DNA
Site652Interaction with DNA

GO annotations

AspectTerm
Cellular Componentchromosome
Molecular FunctionATP binding
Molecular FunctionDNA binding
Molecular FunctionDNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
Biological Processchromosome segregation
Biological ProcessDNA topological change

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    DNA topoisomerase 4 subunit B
  • EC number
  • Alternative names
    • Topoisomerase IV subunit B

Gene names

    • Name
      parE
    • ORF names
      MOLA814_00136

Organism names

Accessions

  • Primary accession
    V4YSC8

Proteomes

Subcellular Location

Interaction

Subunit

Heterotetramer composed of ParC and ParE.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain436-553Toprim

Sequence similarities

Belongs to the type II topoisomerase GyrB family.
Belongs to the type II topoisomerase family. ParE type 1 subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    667
  • Mass (Da)
    73,186
  • Last updated
    2014-01-22 v1
  • Checksum
    BE4837F89A3AD5DA
MSIQFGVMATKNIPTADIAYGESSIRVLKGLEPVKQRPGMYTRTDNPLHIVQEVLDNAADEALAGHGKRIKVILHSDGSVTVEDDGRGIPFGMHPEENAPVVELVFTRLHAGGKFDKGKGGAYNFSGGLHGVGVSVTNALSTRLEVTSYREGQCASLVFSQGDVIEPLTKRALVSGERKTGTTVRVWPQASYFESSTLPLHELTHLLRSKAVLMPGVVVTLVSEKSGETQQWQYKGGLRDYLTQNVHADPVIPMFEGDGFADTNHDTFAEGEGAAWCVAFTEEGQPVRESYVNLIPTNAGGTHDSGLRDGLFTAVKSFIELHALLPKGVKLLPEDVFARASYVLSAKVLDPQFQGQIKERLNSRDAVRLISSFVRPVFELWLNQHVEYGKKLAELVIKAAQHRQKAGQKVEKRKGSGVAVLPGKLTDCESRDLAHNELFLVEGDSAGGSAKMGRDKESQAILPLRGKVLNTWEVDKDRLFANNEIHDIAVAIGVDPHSETDTPDLSGLRYGKICVLSDADVDGSHIQVLLLTLFFKHFPKLIETGHVFVARPPLFRVDAPARGKKPAAKFYALDDGELMAILDKLRKDNVREDSWSISRFKGLGEMNAIQLWDTTLNPDTRRLLPVNLGAWGSQGTAIEFNKLMGKGEAAARRELMERFSDDIEVDI

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AYMW01000001
EMBL· GenBank· DDBJ
ESS14577.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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