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V4Y5M8 · V4Y5M8_9PROT

Function

function

Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.
Plays a role in repairing double-strand DNA breaks, probably involving stabilizing or processing branched DNA or blocked replication forks.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site98-105ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Molecular FunctionATP-dependent DNA damage sensor activity
Molecular Functiondamaged DNA binding
Molecular Functionmetal ion binding
Biological Processrecombinational repair

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    DNA repair protein RadA

Gene names

    • Name
      radA
    • ORF names
      MOLA814_01336

Organism names

Accessions

  • Primary accession
    V4Y5M8

Proteomes

Subcellular Location

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain, motif, region.

Type
IDPosition(s)Description
Domain69-217RecA family profile 1
Motif254-258RadA KNRFG motif
Region352-458Lon-protease-like

Domain

The middle region has homology to RecA with ATPase motifs including the RadA KNRFG motif, while the C-terminus is homologous to Lon protease.

Sequence similarities

Belongs to the RecA family. RadA subfamily.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    458
  • Mass (Da)
    48,420
  • Last updated
    2014-01-22 v1
  • MD5 Checksum
    DFE782A4BADDD3845BF36970D8079150
MAKDKSVYVCNECGATSSKWLGKCPDCNAWNSLQESVVETGNSAGNKNRFQGLAAPQPVANLADIKASDFARLPTQVDELDRVLGGGLVDGGVVLIGGDPGIGKSTLLLQALHTLSLQAPTLYVSGEESGAQVAMRARRLGLDNTQVRVLAEISLERIIATIAAEKPRVCVIDSIQTVYSEALSSAPGSVAQVRECAAHLTRLAKATGVAIILVGHVTKEGTLAGPRVLEHMVDTVLYFEGDTHSSFRLIRAIKNRFGAVNEIGVFAMTERGLKGVANPSAIFLNQHPQPVPGSCVLVTLEGSRPMLVEIQALVDSGGPSPRRLSVGLDRDRLAMLLAVSHRHAGVSCADQDVFVNAVGGVRISEPAADLAVLLAIQSSLRAKPLPKGFVAFGEVGLAGEIRPAPRGQERLREAAKLGFELAIVPKSNAPKKDDPAFKGLTIHAVDRVEEALSWVRGL

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AYMW01000001
EMBL· GenBank· DDBJ
ESS15754.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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