V4N3Q9 · V4N3Q9_EUTSA

Function

function

Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Activity regulation

Allosterically activated by AMP.

Pathway

Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.

Features

Showing features for binding site, site, active site.

Type
IDPosition(s)Description
Binding site86ATP (UniProtKB | ChEBI)
Binding site149-150ATP (UniProtKB | ChEBI)
Binding site174-177ATP (UniProtKB | ChEBI)
Binding site175Mg2+ (UniProtKB | ChEBI); catalytic
Site176Important for substrate specificity; cannot use PPi as phosphoryl donor
Binding site203-205substrate
Active site205Proton acceptor
Binding site248-250substrate
Binding site304substrate
Binding site362-365substrate

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Function6-phosphofructokinase activity
Molecular FunctionATP binding
Molecular Functionmetal ion binding
Biological Processfructose 6-phosphate metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    ATP-dependent 6-phosphofructokinase
  • EC number
  • Short names
    ATP-PFK
    ; Phosphofructokinase
  • Alternative names
    • Phosphohexokinase

Gene names

    • Name
      PFK
    • ORF names
      EUTSA_v10000886mg

Organism names

Accessions

  • Primary accession
    V4N3Q9

Proteomes

Genome annotation databases

Subcellular Location

Keywords

Interaction

Subunit

Homotetramer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain79-386Phosphofructokinase

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    442
  • Mass (Da)
    48,761
  • Last updated
    2014-01-22 v1
  • Checksum
    C3A31569C1D3575C
MTDATIIKKLPSLTGLRQRRNPLEENPFFHPSHGFYINPSDVILSQVVYDLSSDSQPLVAYHRAGPRREILYEPSSVKAAIVTCGGLCPGMNTVIRELVVALWELYGVRQIYGIPAGYRGFYSMEAVELNPKIVHNWHKKGGTVLATSRGGFDLAKIVDAIQIKGYNQVYIIGGDGTMRGAVAIFKEVSRRKMEVGITGIPKTVDNDVGIIDRSFGFQTAVEMAQEAISAAHVEAESAINGIGLVKLMGRSTGHIALHATLSSRDVDCCLIPEMGFYLEGKGGLFEFLEQRLKDNKHAVLVVAEGAGQEMIPRNETQKQERDESGNLVFLDVGVWLKSALKEWWGRDHPGELFTVKYIDPTYMIRAVPANATDNLYCTLLAHSAIHGIMAGYTGFVSGPVNGNYAYIPLEEVAQAKNEVNTSCHKWAWVRSVTNQPDFEKKC

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KI517465
EMBL· GenBank· DDBJ
ESQ39936.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
Help