V4LIW1 · V4LIW1_EUTSA

Function

function

Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
FMN (UniProtKB | Rhea| CHEBI:58210 )

K+ (UniProtKB | Rhea| CHEBI:29103 )

Note: Binds 1 potassium ion per subunit.

Pathway

Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate: step 1/1.
Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxine 5'-phosphate: step 1/1.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site134-138(6S)-NADPHX (UniProtKB | ChEBI)
Binding site135K+ (UniProtKB | ChEBI)
Binding site199K+ (UniProtKB | ChEBI)
Binding site203-209(6S)-NADPHX (UniProtKB | ChEBI)
Binding site241(6S)-NADPHX (UniProtKB | ChEBI)
Binding site244K+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentchloroplast
Cellular Componentcytosol
Cellular Componentmitochondrion
Molecular FunctionFMN binding
Molecular Functionmetal ion binding
Molecular FunctionNADHX epimerase activity
Molecular FunctionNADPHX epimerase activity
Molecular Functionpyridoxamine phosphate oxidase activity
Biological ProcessNADH metabolic process
Biological ProcessNADP metabolic process
Biological Processpyridoxine biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    NAD(P)H-hydrate epimerase
  • EC number
  • Alternative names
    • NAD(P)HX epimerase

Gene names

    • ORF names
      EUTSA_v10013217mg

Organism names

Accessions

  • Primary accession
    V4LIW1

Proteomes

Genome annotation databases

Subcellular Location

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain84-300YjeF N-terminal

Sequence similarities

Belongs to the NnrE/AIBP family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    533
  • Mass (Da)
    59,842
  • Last updated
    2014-01-22 v1
  • Checksum
    C47750C75D4DBA6B
MRSVMRRVTTMTSSFFLQSPPLPISHKPLLSPIPKQYCLSSFLPLPTQRFLTATHGSRLQTFSTKSEPNMQDSGSVSYLTQREAAEIDETLMGPLGFTVDQLMELAGLSVATSIAEVYKPTEYSRVLAICGPGNNGGDGLVAARHLHHFGYKPSICYPKRTDKSLYTGLVTQLESLSIPFVSVDDLPEDLSKDFDVIIDAIFGFSFHGAPRPPFDDLIRRLVSLQNSEKTLQKHPVIASVDIPSGWHVEEGDHEGEGIKPDMLVSLTAPKLCAKRFCGPHHFLGGRFVPPQVAEKYKLELPSYPGTSMCVRIGKPPKVDISAMRVNYVSPELLEDQVESDPTLQFRKWFDEAVAAGLRETNAMALSTTNKDRKPSSRMVLLKGFDENGFVWFTNYESKKGIDLTENPCAALLFYWESLNRQVRIEGPVERISEAESENYYHSRPRGSQIGAIVSKQSSVVPGRHVLYDEYEQLTKKYSDGSLIPKPKNWGGFRLKPNLFEFWQGQPSRLHDRLQYSLHDLNGNPAWRIHRLAP

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KI517464
EMBL· GenBank· DDBJ
ESQ43654.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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