V4L770 · V4L770_EUTSA

Function

function

Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.

GO annotations

all annotationsall molecular functionnucleotide bindingmolecular_functionnucleic acid bindingdna bindingchromatin bindingdna-binding transcription factor activityrna bindingcytoskeletal motor activitycatalytic activitynuclease activitysignaling receptor bindingstructural molecule activitytransporter activitybindingprotein bindingtranslation factor activity, rna bindinglipid bindingkinase activitytransferase activityhydrolase activityoxygen bindingenzyme regulator activitycarbohydrate bindingsignaling receptor activitytranslation regulator activitytranscription regulator activityother molecular functionall biological processcarbohydrate metabolic processgeneration of precursor metabolites and energynucleobase-containing compound metabolic processdna metabolic processtranslationlipid metabolic processtransportresponse to stresscell cyclecell communicationsignal transductioncell-cell signalingmulticellular organism developmentcircadian rhythmbiological_processmetabolic processcatabolic processbiosynthetic processresponse to light stimulusresponse to external stimulustropismresponse to biotic stimulusresponse to abiotic stimulusresponse to endogenous stimulusembryo developmentpost-embryonic developmentfruit ripeningabscissionpollinationflower developmentcellular processprogrammed cell deathphotosynthesiscellular component organizationcell growthprotein metabolic processcellular homeostasissecondary metabolic processreproductive processcell differentiationprotein modification processgrowthepigenetic regulation of gene expressionresponse to chemicalanatomical structure developmentregulation of molecular functionother biological processall cellular componentcellular_componentextracellular regioncell wallintracellular anatomical structurenucleusnuclear envelopenucleoplasmnucleoluscytoplasmmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuscytosolribosomecytoskeletonplasma membranechloroplastplastidthylakoidmembraneexternal encapsulating structureother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentnuclear origin of replication recognition complex
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Molecular Functionchromatin binding
Molecular FunctionDNA replication origin binding
Molecular Functionmetal ion binding
Biological ProcessDNA replication initiation
Biological Processmitotic DNA replication checkpoint signaling
Biological Processresponse to sucrose

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Origin recognition complex subunit 1

Gene names

    • ORF names
      EUTSA_v10029404mg

Organism names

Accessions

  • Primary accession
    V4L770

Proteomes

Genome annotation databases

Subcellular Location

Keywords

  • Cellular component

Interaction

Subunit

Component of the origin recognition complex (ORC) composed of at least ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6. ORC is regulated in a cell-cycle and development dependent manner. It is sequentially assembled at the exit from anaphase of mitosis and disassembled as cells enter S phase. Binds unmodified and methylated histone H3.

Protein-protein interaction databases

Family & Domains

Features

Showing features for region, compositional bias, domain.

Type
IDPosition(s)Description
Region22-147Disordered
Compositional bias87-101Basic and acidic residues
Compositional bias120-129Polar residues
Domain188-237PHD-type
Domain246-363BAH
Region370-415Disordered
Compositional bias371-382Basic and acidic residues
Compositional bias383-399Acidic residues

Sequence similarities

Belongs to the ORC1 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    839
  • Mass (Da)
    95,055
  • Last updated
    2014-01-22 v1
  • MD5 Checksum
    1A759700E87478AB5FF7D44954664E2D
MAAATPKSIKTQTNIYRKSYLSPSSSTLLTPQTPETLTPLRRSARHVSRRIDLGNGQENIASINGRERESIEEMNLIQKRERAPRKRTTDDDFEAKLKKPENLTTPKKKNGKSKKDSLVSEVSFSPVSPNRSETTKKRKKTEEKKTSSNKRVYYNKVEFDGVEFEVGDDVYVKRREDAVSDEEEDPEIEDCRICFKSGSNVMIECDDCLGGFHLKCLKPPLKEVPEGDWICGFCEVRKSGQTLEAPKPPEGKKLMRTAREKLLSSDLWAARIEKLWREADGVYWIRAHWYMIPEETASGRQKHNLKRELYLTNDFADIEMECILRHCFVKCPKEFSKASNDGNDVFLCEYEYDVHWHSFKRLAELADGDSESDHEWNSKKEEEEIDSDDEEMEFDDDEESGRGDSKSKRGGSTSARAANSLKGRFFGLEKVGAKRIPEHVRCHKQTELEKAKATLLLATRPKSLPCRNKEMEEITAFIKGSISDDQCLGRCMYIHGVPGTGKTISVLSVMKNLKAEVEAGSVNPYCFVEINGLKLASPENIYTVIYEALSGHRVSWKKALHSLNERFAEGKKIGKEDDKPCILLIDELDLLVTRNQSVLYNILDWPTKPNSKLIVLGIANTMDLPEKLLPRISSRMGIQRLCFGPYNHTQLQEIISTRLKGIDAFEKPAIEFASRKVAAISGDARRALEICRRAAEVADYRLKSNKTAAKNQLVIMGDVDAAIQEMFQAPHIQVMKSVSKLSKIFLTAMVHELYKTGMAETTFDKVAATVSSFCFSNGEAFPGWDILLKVGCELGECRIILCEPGERHRLQKLQLNFPSDDVAFALKDNKDLPWLANYL

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias87-101Basic and acidic residues
Compositional bias120-129Polar residues
Compositional bias371-382Basic and acidic residues
Compositional bias383-399Acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KI517537
EMBL· GenBank· DDBJ
ESQ38187.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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