V2T5E7 · V2T5E7_9GAMM

Function

function

Catalyzes the transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only aminotransferase known to utilize SAM as an amino donor.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

pyridoxal 5'-phosphate (UniProtKB | Rhea| CHEBI:597326 )

Pathway

Cofactor biosynthesis; biotin biosynthesis; 7,8-diaminononanoate from 8-amino-7-oxononanoate (SAM route): step 1/1.

Features

Showing features for site, binding site.

Type
IDPosition(s)Description
Site14Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM
Binding site49substrate
Binding site109-110pyridoxal 5'-phosphate (UniProtKB | ChEBI)
Binding site142substrate
Binding site243pyridoxal 5'-phosphate (UniProtKB | ChEBI)
Binding site272substrate
Binding site305substrate
Binding site306-307pyridoxal 5'-phosphate (UniProtKB | ChEBI)
Binding site389substrate

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionadenosylmethionine-8-amino-7-oxononanoate transaminase activity
Molecular Functionpyridoxal phosphate binding
Biological Processbiotin biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Adenosylmethionine-8-amino-7-oxononanoate aminotransferase
  • EC number
  • Alternative names
    • 7,8-diamino-pelargonic acid aminotransferase
      (DAPA AT
      ; DAPA aminotransferase
      )
    • 7,8-diaminononanoate synthase
      (DANS
      )
    • Diaminopelargonic acid synthase

Gene names

    • Name
      bioA
    • ORF names
      P256_02086

Organism names

Accessions

  • Primary accession
    V2T5E7

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for modified residue.

TypeIDPosition(s)Description
Modified residue272N6-(pyridoxal phosphate)lysine

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Family & Domains

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    425
  • Mass (Da)
    47,353
  • Last updated
    2014-01-22 v1
  • MD5 Checksum
    036F3E953D57F6F6E3ECA547711A4247
MTDQFDKKHLWHPYTSMLNPLPTFKVKCAYGSTIELEDGRTMIDGMSSWWCTIHGYNHPALNQAVKDQLDKMSHVMFGGLTHEPAIELGKLLLQITPPTLDKIFYADSGSVSVEVALKMAVQYWTAQGKHQKTNFVTTRSGYHGDTWNAMSVCDPVTGMHQVFGSCLPIRYFVPAPQSRYGETWIQEDIQALADTLATHHENIAAMIVEPIVQGAGGMRFYHPEYLRQAKVLCEKYNVLMIFDEIATGFGRTGKMFAWEHANVEPDIMCIGKGLTGGYMTLAATLTNTHMAEVISSGEAGVFMHGPTFMANPLACAVALKSTELLVSQDWQSNIQRIEATLLKHLQPLNDLDTVANVRVLGAIGVVEMKNAVNMAVLQDEFVRRGIWVRPFGRLMYVMPSYVITDDELAFLLTQLAEVVQNQVSA

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AYER01000009
EMBL· GenBank· DDBJ
ESK37653.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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