V1H0P1 · V1H0P1_SALER
- ProteinTyrosine recombinase XerD
- GenexerD
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids298 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Binds cooperatively to specific DNA consensus sequences that are separated from XerC binding sites by a short central region, forming the heterotetrameric XerC-XerD complex that recombines DNA substrates. The complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids. In the complex XerD specifically exchanges the bottom DNA strands.
Activity regulation
FtsK may regulate the catalytic switch between XerC and XerD in the heterotetrameric complex during the two steps of the recombination process.
Features
Showing features for active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Active site | 148 | ||||
Active site | 172 | ||||
Active site | 244 | ||||
Active site | 247 | ||||
Active site | 270 | ||||
Active site | 279 | O-(3'-phospho-DNA)-tyrosine intermediate | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | DNA binding | |
Molecular Function | tyrosine-based site-specific recombinase activity | |
Biological Process | cell division | |
Biological Process | chromosome segregation | |
Biological Process | DNA transposition |
Keywords
- Molecular function
- Biological process
Names & Taxonomy
Protein names
- Recommended nameTyrosine recombinase XerD
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Enterobacteriaceae > Salmonella
Accessions
- Primary accessionV1H0P1
Proteomes
Subcellular Location
Interaction
Subunit
Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD, in which XerC interacts with XerD via its C-terminal region, XerD interacts with XerC via its C-terminal region and so on.
Protein-protein interaction databases
Structure
Family & Domains
Sequence
- Sequence statusComplete
- Length298
- Mass (Da)34,246
- Last updated2014-01-22 v1
- MD5 Checksum5B25BCF8BF7EF3AB1DDE08B7FE21E989
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AOXI01000016 EMBL· GenBank· DDBJ | ESE86203.1 EMBL· GenBank· DDBJ | Genomic DNA |