U6JZS4 · U6JZS4_9EIME

  • Protein
    Fanconi-associated nuclease
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Nuclease required for the repair of DNA interstrand cross-links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions.

Catalytic activity

  • Hydrolytically removes 5'-nucleotides successively from the 3'-hydroxy termini of 3'-hydroxy-terminated oligonucleotides.
    EC:3.1.4.1 (UniProtKB | ENZYME | Rhea)

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentnucleus
Molecular Function5'-3' exonuclease activity
Molecular Function5'-flap endonuclease activity
Molecular Functionflap-structured DNA binding
Molecular Functionmetal ion binding
Biological Processinterstrand cross-link repair

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Fanconi-associated nuclease
  • EC number

Gene names

    • ORF names
      EMH_0046110

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Houghton
  • Taxonomic lineage
    Eukaryota > Sar > Alveolata > Apicomplexa > Conoidasida > Coccidia > Eucoccidiorida > Eimeriorina > Eimeriidae > Eimeria

Accessions

  • Primary accession
    U6JZS4

Proteomes

Organism-specific databases

Subcellular Location

Keywords

  • Cellular component

PTM/Processing

Features

Showing features for signal, chain.

TypeIDPosition(s)Description
Signal1-19
ChainPRO_500571373420-2193Fanconi-associated nuclease

Family & Domains

Features

Showing features for region, compositional bias, coiled coil, domain.

TypeIDPosition(s)Description
Region167-195Disordered
Compositional bias171-195Polar residues
Coiled coil404-435
Domain412-606Transcription factor PAP1
Coiled coil479-553
Region562-586Disordered
Region948-980Disordered
Compositional bias959-980Polar residues
Compositional bias1083-1097Polar residues
Region1083-1216Disordered
Compositional bias1107-1157Polar residues
Compositional bias1178-1216Polar residues
Region1394-1428Disordered
Compositional bias1407-1428Polar residues
Coiled coil1501-1530
Region1532-1660Disordered
Compositional bias1555-1597Polar residues
Compositional bias1618-1660Polar residues
Coiled coil1933-2002
Compositional bias2055-2070Polar residues
Region2055-2146Disordered
Compositional bias2098-2146Polar residues

Sequence similarities

Belongs to the FAN1 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    2,193
  • Mass (Da)
    236,365
  • Last updated
    2014-01-22 v1
  • Checksum
    2B3D92842F25E91A
MPTLRLLLPIRLCVAAAAAAALQHLLLPEEQQCMRRLGVLLGAPRPAAAAATAAATAAAATAAAATAAAATAAAAATAAADATAATPLAAVAVVKEETNPAAAAAAGATASAAAATTDTDTAATAATAAASAAAVNQEAIEEGPLSEGAQLLLSRLLLHLLRLSCSPSQPPAAARRVSSSSSSSISSSSSSSSSNWIRLPPLLRVSREVPHAAAALRELLQRELLLLWTPHTLPPAAAAAAAAPAAAAAAAALLAAGHKPAAAAAAAGSSSSSSRRLEDFFGAPIMQTKNGTQPGAAAAAVAAAGTAAAATPGTAAAAAAAGTAAAAAAAGRAVVPAAVVAAIRVLRVYVITACCCLAQLQQQQLLLRSLRFLFVAVHAPHAAALGPTAATAPGYVVAAAGRLLKEYLQQQQQQKQQQQQQQQQQQQQQQQQEEEVLAFACAALLPAVQRISHLVDLQLRKLPQQQQQQQQQLLLLLLQEAQLQQQEQLQQQGQEQQEQEQQQQLQQQTQQQQEKQQQEEKQEQQQQQHQEQKQQQQQQQQQQLSDAARVEAEAAIRSDTGCYSSSNCCTSSNSSSSSSNSSSSISSSSALATAAGLAKADPEVAAAAENIPAAAAAATTTTAAAAAVAAKTTAVTTWGEAAASQAAAAAAAAAATAVAATAYTAAATDGFQLLPVWRCCCSSCAQLWPVGGAAAAAAATAAAAAEKTAAAAGRTRQQVVDYSVALLAELRMSFAASEATKPGAAAAAAAGAAATAAAAETEALQLAAAAESFLLSHIKEKQAAKQETAAAAAAATAAEAAAATAAAAAAAAKQIKSSSSVYNTGPLEDPLPVAAAATTAAETAATAAATAAASAAAAANSTPTSAAAAAAAAAAVYEARFRAPYLWALVLGQSVQLLEQQRLHAAAADRLLLLLQLHELYTFPAAAAAAAAATAATAAKKQITDIKEKREEGEEAHQEATQQQQQQQQQQQQQQQQQQQRHGLFRHRVGKWYNRLQVLLLQHLQQQQQAAAVGVRCIREGDIVRTAERQEVSRRLIKAALYIHRKRIATSWQQLQQQAIEQQQQQQQQKVLQQQQQQQQQEVLCDTDSSNSDAASSTKPKPRRRRAACSSSSSSSSSSDSSSTSSSSSDSDSDSSRNRSSSSSSSSSSSSKSLHATRSRRPPPRPPPRKRRRAVNTPESSKNSSSSSSSRTSSSKSSPRGAPKQQQQQQQQQQEEEYEFLRVLPVDVHACVLDAYKEEQQLQQELPICVVSARPLAAAAAAGRSSIFVGWDAQLLRVEELALQHYKLAGGWRGHHDEGAAIRSLFLILTAAAQQQQQQQQQQQQGDCLLMGRIMQTNTQQQQQQQLQQQQEGGDRLLLLLQLHELYTFPPAAAAAAATAATAATAATEQITDMKEKREEGEEAHQEASQQQQQQQQQQQQQQQQQQQRHGLFRHRVGKWYNRLQVLLLQHLQQQQQAAAVGVRCIREGDIVRTAERQEVSRRLIKAALYIHRKRIATSWQQLQQQAIEQQQQQQKVLQQQQQQQQQQQEVLCDTDSSNSDAASSTKPKPRRRRAACSSSSSSSDSSSTSSSSSDSDSDSSRNRSSSSSSSKSLHATRSKRPPPRPPPRKRRRAVNAPESSKNSSSSSSSSRTSSSRSSPRGAQKQQQQQQQQQQQQQQQQQLEEEYEFLRVLPVDVHACVLDAYKEEQQLQQELPVCVVSARPLAAAAAAGRSSIFVGWDAQLLRVEELALQHYKLAGGWRGHHDEGAAIRSLFLILTAAAQQQQQQQQQQQQGDCLLMGRIMQTNTHQQQQQLLQQQQEGGGAAADRSIAVAFLPAADPTEQQLLPIEQQQQQQLLLQQLQHSSSNQVHALFKQAVAAVYGQQIRGVSWGWEASVGTPLLQQQQQQQQQQQQQQQQQQQKRQQQSSLLDDELDDDIADELEDCLLSLGAPLLQQQQQQQQQQQQQQQQQQQKRQQQSSLLDDELDEDIGDELEDCLLQQQQQQQQQQQQQQQQQQQQQDRAADCAEFYSRIAAAIGGPALSSIFSLLLEDYRGWAPGLPDLLLWRPKQQQQQQQQQQQQQQEQQQEEEGKQQQNGKQEKGPSQTELLKEPDLLLWRPKQQQQQQQQQQQQQQQQEQQQQEEGKQQQNGKEEKGPSQTELSKEQQQQQQQQQQQQQQQQQQQQQQQQQQQEEWEVMLVEVKGPRDTLSNKQK

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias171-195Polar residues
Compositional bias959-980Polar residues
Compositional bias1083-1097Polar residues
Compositional bias1107-1157Polar residues
Compositional bias1178-1216Polar residues
Compositional bias1407-1428Polar residues
Compositional bias1555-1597Polar residues
Compositional bias1618-1660Polar residues
Compositional bias2055-2070Polar residues
Compositional bias2098-2146Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
HG681679
EMBL· GenBank· DDBJ
CDJ29013.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp