U6GNX1 · U6GNX1_9EIME
- ProteinAlpha-1,3/1,6-mannosyltransferase ALG2
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids257 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Mannosylates Man2GlcNAc2-dolichol diphosphate and Man1GlcNAc2-dolichol diphosphate to form Man3GlcNAc2-dolichol diphosphate.
Catalytic activity
- an alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP-alpha-D-mannose = an alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP + H+
an α-D-Man-(1→3)-β-D-Man-(1→4)-β-D-GlcNAc-(1→4)-α-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol RHEA-COMP:19513 + CHEBI:57527 = an α-D-Man-(1→3)-[α-D-Man-(1→6)]-β-D-Man-(1→4)-β-D-GlcNAc-(1→4)-α-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol RHEA-COMP:19515 + CHEBI:58189 + CHEBI:15378
Pathway
Protein modification; protein glycosylation.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum membrane | |
Molecular Function | alpha-1,3-mannosyltransferase activity | |
Molecular Function | GDP-Man:Man1GlcNAc2-PP-Dol alpha-1,3-mannosyltransferase activity | |
Molecular Function | GDP-Man:Man2GlcNAc2-PP-dolichol alpha-1,6-mannosyltransferase activity | |
Biological Process | oligosaccharide-lipid intermediate biosynthetic process | |
Biological Process | protein glycosylation |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameAlpha-1,3/1,6-mannosyltransferase ALG2
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Sar > Alveolata > Apicomplexa > Conoidasida > Coccidia > Eucoccidiorida > Eimeriorina > Eimeriidae > Eimeria
Accessions
- Primary accessionU6GNX1
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Endoplasmic reticulum membrane ; Single-pass membrane protein
Keywords
- Cellular component
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 69-133 | Glycosyl transferase family 1 | ||||
Sequence: DLSAPFVVSLNRFEEKKDVELAIKAVARLPRQIKCNLIVAGGFDPRLPECNDYFQRLVKLSKELN | ||||||
Domain | 154-212 | Glycosyl transferase family 1 | ||||
Sequence: VPCEAMFVGCLPVACNTGGPRETIVDRETGFLCPPTPESFSAALKHILLLSLENPEELA |
Sequence similarities
Belongs to the glycosyltransferase group 1 family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length257
- Mass (Da)28,581
- Last updated2014-01-22 v1
- ChecksumE0288172C3A02602
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
HG691828 EMBL· GenBank· DDBJ | CDI80304.1 EMBL· GenBank· DDBJ | Genomic DNA |