U6G9T9 · U6G9T9_EIMAC

Function

function

Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Pathway

Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.

Features

Showing features for binding site, site, active site.

TypeIDPosition(s)Description
Binding site307ATP (UniProtKB | ChEBI)
Binding site371-372ATP (UniProtKB | ChEBI)
Binding site400-403ATP (UniProtKB | ChEBI)
Binding site401Mg2+ (UniProtKB | ChEBI); catalytic
Site402Important for substrate specificity; cannot use PPi as phosphoryl donor
Binding site429-431substrate
Active site431Proton acceptor
Binding site476-478substrate
Binding site537substrate
Binding site634-637substrate

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Function6-phosphofructokinase activity
Molecular FunctionATP binding
Molecular Functiondiphosphate-fructose-6-phosphate 1-phosphotransferase activity
Molecular Functionmetal ion binding
Biological Processfructose 6-phosphate metabolic process
Biological Processresponse to glucose

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Probable ATP-dependent 6-phosphofructokinase
  • EC number
  • Short names
    ATP-PFK
    ; Phosphofructokinase
  • Alternative names
    • Phosphohexokinase

Gene names

    • ORF names
      EAH_00020360

Organism names

  • Taxonomic identifier
  • Strain
    • Houghton
  • Taxonomic lineage
    Eukaryota > Sar > Alveolata > Apicomplexa > Conoidasida > Coccidia > Eucoccidiorida > Eimeriorina > Eimeriidae > Eimeria

Accessions

  • Primary accession
    U6G9T9

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Interaction

Subunit

Tetramer of two alpha (regulatory) and two beta (catalytic) chains.

Family & Domains

Features

Showing features for region, domain, coiled coil, compositional bias.

TypeIDPosition(s)Description
Region1-60Disordered
Region80-139Disordered
Domain299-552Phosphofructokinase
Domain866-1049Phosphofructokinase
Coiled coil1073-1100
Region1268-1288Disordered
Region1411-1452Disordered
Compositional bias1437-1452Polar residues

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,452
  • Mass (Da)
    159,809
  • Last updated
    2014-01-22 v1
  • Checksum
    7717A352410DE03D
MPGERLPLGGQGAHKTTNAPPLPAHRSPSGRPGGGALPTGAGGAAGAAAAAGGVGAGVGLPAHLRRGRSLLVLTQDNQYKLSAPPADPHGARSPSRDAWRPTITTGPAQSPKTPGERELVAPASGAPQAARQQQGSRPVKRFSFRAGVGLSIDARSRQLSRRLSSFGMTEGNVFGSLATNAPSEAPPSVDAVLKEQETNGKVHLHSADLFERSSPLQRLRRAWRCTLPSALESTQLRLVEADCPVEHPSLRQTPEVQQQLRGFFPATFGKKYVEVVPGMGSGVASPKEPLDHPLSKALRIGIVLSGGPAPGGHNVIAGLYDFVKQKHPESMLVGFMGGLDGVMNQNYTVVTEELMEDFRNQGGFDMLWSGRGRVGGEEDIQRAREVCESLELHGFVLVGGDGSNSNAALLAESFEKDLPSCCVIGVPKTIDGDLKNALIEASFGFDTAAKTYSELIGNLCIDVNSSQKVYHFVRVMGRSASHLVLECAMQARPNLVFIGEEVERENMSLEHIVQELVDLVVKRAEQGKMYGVILVPEGLIEFIPEMKQLIKELNSVLKAGQPFKPELLKTTRAVWDFLPDVIQDQLLMDRESTGYIQVAKIATERLLILLLENELVKQGKDPEQWSFMPHYFGYEGRCAMPSNFDANYCYSLGFVAGVPFTTMMCVKEDAKGVAFPAITRSLVDLDGPLFKVFCEAREHWKFGDYYRVPGPIQFEGPTADEPAYAVSIPTKEELLHQSEAICHVGVGGRVVKSFGFLSALQRERLTHRPPVPPLCLDPKCKARPMKQVLCKDPYTQRQVLMHYPYLANSTLFYLHEVAHDKYTPPINYGLRVGFVLLSRQSPGVMNVLWGLHERLKMVQGKCLAFFGLTGLIEKNYIEITDENLELFLNQGGCELTGRSTSHCLGSVENQEAVRQRCEELMLDGLVMPGSAFAMSEAALVAEYFLARQCRTSIIGIPATGSNNLAGEFIETCVGFDSSTKVYAALIGNVLTDAASMPKYWHFIRLMGRQPSFEVLECALQTHPNVVIIAEEYGAADKTLLHVVQDIADVVCRRAELGRNFGTVLIPDALLMHLPNMKILLAELRRIIREAQAKGEMKKAQVSQQLMDVDSWAANEPDSWNWRLTPWSAALFKTFPKFIRRELVQVDMGEIRFERLETEELLAQMVKEELEYRASVGRYCGKFQAVTHFFGYQGRSSMPSTFDANLAYAYGNLASILVESGVTGHCCSIRGLCGNPKEWHLGSVPFVSLMRLVPNVQDNPTLTAATQKTGTSAADGVMDRTSRTPSVTEQPVIPSSEVSLDGKAYRWMKTALEQWMMEDRFCNPGPIQFYGASPDMRRQPPCVGATFFNRVLYEEQAEYFDMVRRVECYTNILRNTCSFGVSDHILKHAFVSLTGLLMLVFHSDELTTRMPALGQSDETDFTDVEPAALRKTTWRDQGGQLGRPSSSSKHPGN

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias1437-1452Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
HG670489
EMBL· GenBank· DDBJ
CDI76905.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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