U6G6P8 · U6G6P8_9EIME

  • Protein
    DNA topoisomerase 2
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks.

Catalytic activity

  • ATP-dependent breakage, passage and rejoining of double-stranded DNA.
    EC:5.6.2.2 (UniProtKB | ENZYME | Rhea)

Cofactor

Protein has several cofactor binding sites:
Ca2+ (UniProtKB | Rhea| CHEBI:29108 )

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentmembrane
Molecular FunctionATP binding
Molecular FunctionDNA binding
Molecular FunctionDNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
Biological ProcessDNA topological change

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    DNA topoisomerase 2
  • EC number

Gene names

    • ORF names
      EPH_0044700

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Houghton
  • Taxonomic lineage
    Eukaryota > Sar > Alveolata > Apicomplexa > Conoidasida > Coccidia > Eucoccidiorida > Eimeriorina > Eimeriidae > Eimeria

Accessions

  • Primary accession
    U6G6P8

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane880-901Helical

Keywords

  • Cellular component

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for region, compositional bias, domain.

TypeIDPosition(s)Description
Region161-211Disordered
Compositional bias195-211Basic and acidic residues
Domain389-503Toprim

Sequence similarities

Belongs to the type II topoisomerase family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    905
  • Mass (Da)
    102,177
  • Last updated
    2014-01-22 v1
  • Checksum
    6AAC392BCF9DAE7E
MHAGIPVAIHKEHKVYVAELIFGQLLTSDNYDDTEARVTGGRNGFGAKLTNIFSTYFEVECADSKRKQKIKVVWTDNMSKQEPPVITPFNGAGDFVSVKFKPDLRRFGMSALDDDLVSLLRKRCFDLAGTAGTAVYWNGTRLPVRNFVDYVDLYLGEGAGRKRGGKGKEKDRKKAKKKGSDGESSDDSDADEGEKENGIEPKDDEDKENERLPEKQIIKIHEKMHRWEVVISQTDGGSFSQVSFVNSICTTKGGHHVTHVIEPLLAALVKKANAKNKGGMEIKAPHVKQHLWVFVKCLIENPAFDSQTKETLTTTVSRFGSKCTLSERTINAVAKSPILEGVLLWAQTKAQVELRRQMSVGKTKGRERLTGISKLEDANEAGGRYAQECTLILTEGDSAKTSCLAGLSVVGREKYGVFPLRGKLLNVREASFKQLKENREIQNILRILGLQINDKVQDTRGLRYGSLMIMTDQDYDGSHIKGLLINMLHHYWPQLLQCNHFLTEFVTPIVKVSKGSVEKAFFTLVEYDMWRKQAGNLAGWKIKYYKVGSGDGELIDMAFSKKRAEDRKRWLQGYREGTFVDHSMRELTFSDFVNKELVQFSRYDNERSIPQLVDGWKLVDGWKVGQRKVLFAVFKKNTKAEMKVAQLSGYVAEQSAYHHGEQSLQQTIITMAQRFVGSNNLNFLEPVGQFGSRKEGGKDASAPRYIFTKLAPYTRLVFPEADDPLLEYLYEEGQKIEPKYYVPVIPTILVNGSEGIGTGWSSFIPNFNPKDIISNLKRFIAGEEMVRMKPWYRGFKGLIEENSTRTAFETIGLIEKKGEDVVEISELPIKRWTQDYKEWLEEQLPTPDKKDPWISDFRDSSSHEDIKFVVKLSAGKVPSFGVHFLVGGLSCTCVAASLCIYRPLY

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias195-211Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
HG691224
EMBL· GenBank· DDBJ
CDI75926.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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