U6CU29 · U6CU29_NEOVI

Function

Catalytic activity

  • 1-O-decyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-decyl-sn-glycero-3-phosphocholine + acetate + H+
    This reaction proceeds in the forward direction.
  • 1-O-dodecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-dodecyl-sn-glycero-3-phosphocholine + acetate + H+
    This reaction proceeds in the forward direction.
  • 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphocholine + acetate + H+
    This reaction proceeds in the forward direction.
  • 1-O-octadecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-octadecyl-sn-glycero-3-phosphocholine + acetate + H+
    This reaction proceeds in the forward direction.
  • 1-O-tetradecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-tetradecyl-sn-glycero-3-phosphocholine + acetate + H+
    This reaction proceeds in the forward direction.
  • 1-hexadecanoyl-2-(10-hydroperoxy-8E-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + 10-hydroperoxy-(8E)-octadecenoate + H+
    This reaction proceeds in the forward direction.
  • 1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + 5-oxopentanoate + H+
    This reaction proceeds in the forward direction.
  • 1-hexadecanoyl-2-(9-oxononanoyl)-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + 9-oxononanoate + H+
    This reaction proceeds in the forward direction.
  • 1-hexadecanoyl-2-[9-hydroperoxy-(10E-octadecenoyl)]-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + 9-hydroperoxy-10E-octadecenoate + H+
    This reaction proceeds in the forward direction.
  • 1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + acetate + H+
    This reaction proceeds in the forward direction.
  • 1-hexadecanoyl-2-butanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + butanoate + H+
    This reaction proceeds in the forward direction.
  • 1-hexadecanoyl-2-glutaroyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + glutarate + H+
    This reaction proceeds in the forward direction.
  • 1-hexadecanoyl-2-pentanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + H+ + pentanoate
    This reaction proceeds in the forward direction.
  • 1-hexadecanoyl-2-propionyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + H+ + propanoate
    This reaction proceeds in the forward direction.
  • a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + acetate + H+
    This reaction proceeds in the forward direction.
    EC:3.1.1.47 (UniProtKB | ENZYME | Rhea)

Features

Showing features for active site.

TypeIDPosition(s)Description
Active site275Nucleophile
Active site298Charge relay system
Active site353Charge relay system

GO annotations

AspectTerm
Cellular Componenthigh-density lipoprotein particle
Cellular Componentlow-density lipoprotein particle
Molecular Function1-alkyl-2-acetylglycerophosphocholine esterase activity
Molecular Functioncalcium-independent phospholipase A2 activity
Molecular Functionphospholipid binding
Biological Processlipid oxidation
Biological Processlow-density lipoprotein particle remodeling
Biological Processphosphatidylcholine catabolic process
Biological Processplasma lipoprotein particle oxidation
Biological Processplatelet activating factor catabolic process
Biological Processpositive regulation of monocyte chemotaxis

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Platelet-activating factor acetylhydrolase
  • EC number

Gene names

    • Name
      PAFA

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Carnivora > Caniformia > Musteloidea > Mustelidae > Mustelinae > Neogale

Accessions

  • Primary accession
    U6CU29

Proteomes

Subcellular Location

Keywords

  • Cellular component

PTM/Processing

Features

Showing features for signal, chain.

TypeIDPosition(s)Description
Signal1-21
ChainPRO_504066426522-445Platelet-activating factor acetylhydrolase

Keywords

Family & Domains

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    445
  • Mass (Da)
    49,954
  • Last updated
    2014-01-22 v1
  • Checksum
    63378AF46D95724E
MLPPKVHALFCLCSCLALVHPIDWQDLNPVAQIRSSAWANKIQALMAAASVGQSKIPKGNGSYSVGCTDLMFDYTKKGTFLRLYYPSQEEDHHSDTLWIPNKEYFFGLSKYLGTHWLMGKILSLFFGSMTTPAEWNSPLRTGEKYPLIVFSHGLGAFRTIYSAIGIDLASYGFIVAAVEHRDGSASATYYFQDQSAAEIGNKSWLYLQSLKTEEEEMSVRSEQVQKRAKECSQALDLILDIDRGRPVKNVLDLEFDVEQLKDSIDRDKIAVIGHSFGGATVVQTLSEDQRFRCGIALDAWMAPLDDEIFPRIPQPLFFINSERFQYPANIEKMEKCYSPGKERKMITIRGSVHQNFADFTFATGKIIGYIFTLKGDIDSNVALGLSNKASLAFLQKHLGLQKDFDQWDSLIEGKDANLIPGTNINITSHDVSLQNSTETEQQHLD

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A0A8C7ENJ0A0A8C7ENJ0_NEOVI430

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
HAAF01001988
EMBL· GenBank· DDBJ
CCP73814.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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