U5TBE3 · U5TBE3_COWPX

  • Protein
    CPXV197 protein
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    2/5

Function

function

Nuclease that is responsible for viral evasion of host cGAS-STING innate immunity. Cleaves 2',3'-cGAMP which is produced by host cGAS following recognition of cytosolic DNA and blocks the subsequent 2',3'-cGAMP-mediated activation of TMEM173/STING, which normally spreads to adjacent cells and activates the interferon and NF-kappa-B immune responses.

Catalytic activity

Features

Showing features for active site, site.

150450100150200250300350400450500
TypeIDPosition(s)Description
Active site17Proton donor
Site60Substrate binding
Site105Substrate binding
Active site138Shared with catalytic histidine of dimeric partner
Active site142Proton acceptor; shared with catalytic histidine of dimeric partner
Site149Substrate binding
Site169Substrate binding
Site182Substrate binding
Site184Substrate binding
Site186Substrate binding

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Molecular Function2',3'-cyclic GMP-AMP binding
Molecular Functionnuclease activity
Biological Processsymbiont-mediated suppression of host innate immune response

Keywords

Names & Taxonomy

Protein names

  • Submitted names
    • CPXV197 protein

Gene names

    • ORF names
      CPXV197

Organism names

Accessions

  • Primary accession
    U5TBE3

Proteomes

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain244-356Poxin-Schlafen/Schlafen-like N-terminal
Domain374-484Schlafen AlbA-2

Domain

The substrate binding site is formed by the N-terminus of a monomer and the C-terminus of the opposite monomer.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    504
  • Mass (Da)
    57,202
  • Last updated
    2014-01-22 v1
  • Checksum
    96570EB5E73536B7
MAMFYAHALGGYDENLHAFPGISSTVANDVRKYSVVSVYNNKYDIVKDKYMWCYSQVNKRYIGALLPMFECNEYLQIGDPIHDQEGNQISIVTYRHKNYYALSGIGYESLDLCLEGVGIHHHVLETGNAVYGKVQHDYSTIKEKAKEMNSLSPGPIIDYHVWIGDCICQVTAVDVHGKEIMRMRFKRGAVLPIPNLVKVKVGEENDTVNLSTSISALLNSGGGTIEVTSKEERVDYVLMKRLESIRHLWSVVYDHFDVVNGEERCYVHMHSSNQSPMLSTVKTNLYMKTMGACLQMDSMEALEYLSELKESGGRSPRPELQKFEYPDGVEDAGSIERLAEEFFSRSELQAGESVKFGNSINVKSTSVSAKQLRTRIRQQLPSILSSFANTDGGYLFIGVDNNTHKVVGFTVGQDYLKLVESEIEKRIRRLHVVHFCEKKEDIKYACRFIKVYKPGEETTSTYVCAIKVERCCCAVFADWPESWYMDTSGIKKYSPDEWVSSIKF

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KC813496
EMBL· GenBank· DDBJ
AGY98136.1
EMBL· GenBank· DDBJ
Genomic DNA
MK035751
EMBL· GenBank· DDBJ
AZY89890.1
EMBL· GenBank· DDBJ
Genomic DNA
MK035752
EMBL· GenBank· DDBJ
AZY90075.1
EMBL· GenBank· DDBJ
Genomic DNA
MK035754
EMBL· GenBank· DDBJ
AZY90444.1
EMBL· GenBank· DDBJ
Genomic DNA
MK035755
EMBL· GenBank· DDBJ
AZY90629.1
EMBL· GenBank· DDBJ
Genomic DNA
MK035756
EMBL· GenBank· DDBJ
AZY90819.1
EMBL· GenBank· DDBJ
Genomic DNA
MK035758
EMBL· GenBank· DDBJ
AZY91192.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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