U5GXS3 · U5GXS3_USTV1

Function

function

Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.
Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.

Catalytic activity

Cofactor

biotin (UniProtKB | Rhea| CHEBI:57586 )

Features

Showing features for binding site, active site.

111921002003004005006007008009001,0001,100
Type
IDPosition(s)Description
Binding site155ATP (UniProtKB | ChEBI)
Binding site239ATP (UniProtKB | ChEBI)
Binding site274ATP (UniProtKB | ChEBI)
Active site330
Binding site585Mn2+ (UniProtKB | ChEBI)
Binding site657substrate
Binding site755Mn2+ (UniProtKB | ChEBI); via carbamate group
Binding site785Mn2+ (UniProtKB | ChEBI)
Binding site787Mn2+ (UniProtKB | ChEBI)
Binding site920substrate

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionATP binding
Molecular Functionmetal ion binding
Molecular Functionpyruvate carboxylase activity
Biological Processgluconeogenesis
Biological Processpyruvate metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Pyruvate carboxylase
  • EC number

Gene names

    • ORF names
      MVLG_00001

Organism names

Accessions

  • Primary accession
    U5GXS3

Proteomes

Subcellular Location

PTM/Processing

Features

Showing features for modified residue.

TypeIDPosition(s)Description
Modified residue755N6-carboxylysine
Modified residue1156N6-biotinyllysine

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for region, domain.

Type
IDPosition(s)Description
Region9-34Disordered
Domain39-488Biotin carboxylation
Domain159-355ATP-grasp
Domain576-846Pyruvate carboxyltransferase
Domain1112-1190Lipoyl-binding

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,192
  • Mass (Da)
    129,997
  • Last updated
    2013-12-11 v1
  • MD5 Checksum
    D03E33F356E8CB50AA1ED9DA146DDF45
MADVALALKTPKQSRPGSPGGSASPSINNLRQLGRGAQPPRKLLVANRGEIAIRIIRTAHELGMTTVAIYSKEDRFSAHRNKADESFLVGEGLTPVAAYLDYKNIIKIAVEHSVTMIHPGYGFLSENADFAKAVEDAGLLFVGPQPSVIDGLGDKIKARTLAIQIGVPVVPGTPGAISTYEEANDFVEKYGFPVIIKAAMGGGGRGMRVVRTAKDFKDAFAMATSEAKSAFGDGTVFVERFLDKPKHIEAQLIGDSHGNIVHLFERDCSVQRRHQKVVELAPASNISEELRTQLLADAVKIAKAVKYRNAGTCEFLVDSKGHYFIEINPRIQVEHTITEEITGIDIVAAQIQIAAGASLPELGLTQDTITKRGYAIQCRITTEDPAANFQPDTGKIEVYRSAGGNGVRLDASSGFAGAQITPHYDSLLVKCTVRGATFEIARRKMLRALVEFRIRGVKTNIPFLFRVLSHESFITNNTWTTFIDDTPQLFQLVTSQNRAQKFLAYLGDLVVNGSTIKGQMGEPGLNEEIPIPAIVDPKDETKALETSEPCTTGWRNIIVEQGPEAFAKAVRAYPGVLIMDTTWRDAHQSLIATRLRTVDMANIAKETSHALSNAYALECWGGATFDVAMRFLYEDPWERLRSLRKLVPNIPFQALVRGANAVGYTSYPDNAIYEFSRKAVENGLDIFRVFDSLNYIDNMRLGIDAAKKAGGVVEAAICYTGDVANPKKHSKYTLEYYLQFAQELVDCGIHVLAIKDMAGILKPEAATILVGALRKKFPDLPIHVHSHDTAGISVSSMLACAAAGADVVDVAIDSMSGTTSQPSMGAVCSALEQTNLGTGISHENIQALNLYWSSVRTLYSCFDANVRASDSGVFDHEMPGGQYTNLMFQSTQLGLTGRWKEVVKSYIDANLLCGDIVKVTPSSKVVGDFAQFLVANKLTRQDVIDQADKLDFPNSVVEFFQGYLGQPTGGFPEPLRSKIIRDKKRIDERPGKDMEPYDFEGTRAKLIEKYGSTITSTDVLSYCMYPKVFEEFKEFTTKYGDLSVLPTRFFLGKPPVGKEIHIAMEKGKTLIVKLIAVSPVDTSSGTRDILFELNGELRAVQVEDRSAAIETVHREKATNEPGSVGSPMSAVVVEVRVHEGQEVKAGDPICVLSAMKIEQIVSAPVSGKVQRVSVQPSDSIAQGDLVAVIQHS

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
U5GXS4U5GXS4_USTV1MVLG_000011129

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AEIJ01000001
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
GL541643
EMBL· GenBank· DDBJ
KDE09592.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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