U4UUH2 · U4UUH2_DENPD
- Protein4-trimethylaminobutyraldehyde dehydrogenase
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids485 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Converts gamma-trimethylaminobutyraldehyde into gamma-butyrobetaine with high efficiency (in vitro). Can catalyze the irreversible oxidation of a broad range of aldehydes to the corresponding acids in an NAD-dependent reaction, but with low efficiency. Catalyzes the oxidation of aldehydes arising from biogenic amines and polyamines.
Catalytic activity
- (5-hydroxyindol-3-yl)acetaldehyde + H2O + NAD+ = (5-hydroxyindol-3-yl)acetate + 2 H+ + NADH
- 3,4-dihydroxyphenylacetaldehyde + H2O + NAD+ = 3,4-dihydroxyphenylacetate + 2 H+ + NADH
- H2O + NAD+ + pentanal = 2 H+ + NADH + pentanoate
- H2O + NAD+ + propanal = 2 H+ + NADH + propanoate
- H2O + NAD+ + spermine monoaldehyde = 2 H+ + N-(2-carboxyethyl)spermidine + NADH
- H2O + hexanal + NAD+ = 2 H+ + hexanoate + NADH
- H2O + imidazole-4-acetaldehyde + NAD+ = 2 H+ + imidazole-4-acetate + NADH
- acrolein + H2O + NAD+ = acrylate + 2 H+ + NADH
- butanal + H2O + NAD+ = butanoate + 2 H+ + NADH
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 247 | |||||
Sequence: E |
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | betaine-aldehyde dehydrogenase activity | |
Molecular Function | metal ion binding | |
Biological Process | glycine betaine biosynthetic process from choline |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name4-trimethylaminobutyraldehyde dehydrogenase
- EC number
- Alternative names
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Coleoptera > Polyphaga > Cucujiformia > Curculionidae > Scolytinae > Dendroctonus
Accessions
- Primary accessionU4UUH2
Proteomes
PTM/Processing
Keywords
- PTM
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 12-474 | Aldehyde dehydrogenase | ||||
Sequence: DSTGGETFPAINPANGETLAEVASATREDLDRAVVAAQKGQKIWAAMTAMQRSRILRKAVDILRDRNDELAQIETLDTGKPLSETTAVDIVTGADVLEYYAGLIPAIEGQQIPLRDSAFVYTRREPLGVVAGIGAWNYPIQIALWKSAPALAAGNAMIFKPSEVTSLTALKLAEIYTAAGVPDGVFSVLTGKGAEIGQYLTEHPGIAKISFTGGVVTGKKVMASASASTLKEVTMELGGKSPLIVFPDADLDKAADIAMMANFYSSGQVCTNGTRVFVPKTLQGEFEAKILERVKRIKLGQPTDEAVNFGPLVSFAHMENVLRFIDSGKREGARLLIGGERVTSGEYGKGAFVAPTVFTDCRDEMEIVREEIFGPVMSILTYESEDEVIRRANDTDYGLAAGLVTRDLNTAHRVIHQLEAGICWINTWGESAAEMPVGGYKHSGVGRENGVSTLEHYTQIKSV |
Sequence similarities
Belongs to the aldehyde dehydrogenase family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length485
- Mass (Da)52,353
- Last updated2013-12-11 v1
- ChecksumF67CFE82328F04E0
Keywords
- Technical term