U4UMW9 · U4UMW9_DENPD

Function

function

Lysosomal dipeptide uniporter that selectively exports lysine, arginine or histidine-containing dipeptides with a net positive charge from the lysosome lumen into the cytosol. Could play a role in a specific type of protein O-glycosylation indirectly regulating macrophages migration and tissue invasion. Also essential for liver homeostasis.

Catalytic activity

  • L-alanyl-L-lysine(out) = L-alanyl-L-lysine(in)
  • L-alpha-aminoacyl-L-arginine(out) = L-alpha-aminoacyl-L-arginine(in)
  • L-alpha-aminoacyl-L-histidine(out) = L-alpha-aminoacyl-L-histidine(in)
  • L-alpha-aminoacyl-L-lysine(out) = L-alpha-aminoacyl-L-lysine(in)
  • L-arginyl-L-alpha-amino acid(out) = L-arginyl-L-alpha-amino acid(in)
  • L-arginyl-glycine(out) = L-arginyl-glycine(in)
  • L-aspartyl-L-lysine(out) = L-aspartyl-L-lysine(in)
  • L-histidyl-L-alpha-amino acid(out) = L-histidyl-L-alpha-amino acid(in)
  • L-histidyl-glycine(out) = L-histidyl-glycine(in)
  • L-lysyl-L-alanine(out) = L-lysyl-L-alanine(in)
  • L-lysyl-L-alpha-amino acid(out) = L-lysyl-L-alpha-amino acid(in)
  • L-lysyl-L-lysine(out) = L-lysyl-L-lysine(in)
  • L-lysyl-glycine(out) = L-lysyl-glycine(in)

GO annotations

AspectTerm
Cellular Componentlysosomal membrane
Molecular Functiontransmembrane transporter activity

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Lysosomal dipeptide transporter MFSD1
  • Alternative names
    • Major facilitator superfamily domain-containing protein 1

Gene names

    • ORF names
      D910_08841

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Coleoptera > Polyphaga > Cucujiformia > Curculionidae > Scolytinae > Dendroctonus

Accessions

  • Primary accession
    U4UMW9

Proteomes

Subcellular Location

Lysosome membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane32-52Helical
Transmembrane73-95Helical
Transmembrane107-125Helical
Transmembrane203-225Helical
Transmembrane255-274Helical
Transmembrane286-306Helical
Transmembrane313-332Helical
Transmembrane338-363Helical
Transmembrane370-389Helical
Transmembrane401-423Helical

Keywords

Interaction

Subunit

Homodimer. Interacts with lysosomal protein GLMP (via lumenal domain); the interaction starts while both proteins are still in the endoplasmic reticulum and is required for stabilization of MFSD1 in lysosomes but has no direct effect on its targeting to lysosomes or transporter activity.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain33-426Major facilitator superfamily (MFS) profile

Sequence similarities

Belongs to the major facilitator superfamily.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    497
  • Mass (Da)
    55,180
  • Last updated
    2013-12-11 v1
  • Checksum
    7A39A8E8B95E5317
MEGGPNIQVAVEDEETCCDRAYHLCCHPSGKAHRFLALIFMCILGFGSYFCYDNPSALQKQFKQDLNLTETQFTALYSVYSWPNVVMCFVGGFLIDQVFGIRAGANIFMGLTLIGQLLFTAAVYVNQYWLMILGRFVFGVGSESLAVAQNNYAVLWFKGKELNMVFGLQMSIARMGSTVNFWLMEPIYQWVSTSSTGTKILGLSLLIASATCLFSTICSLILGYMDKRAERMTRRSEARTTEAVRITDAKHFKGTFWLVTCICVTYYNAIFPFISLAQMNVKDADHISSLIYLISGIISPFTGFLIDKIGLNILWILISTVGTIIAHLLLGFTACDPYIGVIILGVAYSVLASGLWPLVAVIIPEYQLGTAYGVCQAVQNLGLAIVSIITGSIVDKWGFRVLSMFFLGNLFMAFMFTSILLIIDQRERGVLNLTPGGRKKHQEVILEEIVQRQRLLSAEQLPVDVEAPAQESADNNSGSDDTRLRNRYISAVDRLSS

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KB632288
EMBL· GenBank· DDBJ
ERL91511.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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