Essential maintenance is planned to begin on Fri Jan 24 2025. The website may be temporarily unavailable. Please use our fallback: https://wwwdev.ebi.ac.uk/uniprot/front-end/fallback/ in case of any outage.

U4U691 · U4U691_DENPD

Function

Catalytic activity

  • Catalyzes the rearrangement of -S-S- bonds in proteins.
    EC:5.3.4.1 (UniProtKB | ENZYME | Rhea)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentendoplasmic reticulum lumen
Molecular Functionprotein disulfide isomerase activity
Biological Processprotein folding
Biological Processresponse to endoplasmic reticulum stress

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Protein disulfide-isomerase
  • EC number

Gene names

    • ORF names
      D910_03559

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Coleoptera > Polyphaga > Cucujiformia > Curculionidae > Scolytinae > Dendroctonus

Accessions

  • Primary accession
    U4U691

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for signal, chain, disulfide bond.

Type
IDPosition(s)Description
Signal1-18
ChainPRO_500514768919-492Protein disulfide-isomerase
Disulfide bond50↔53Redox-active
Disulfide bond395↔398Redox-active

Keywords

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain7-130Thioredoxin
Domain327-473Thioredoxin

Sequence similarities

Belongs to the protein disulfide isomerase family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    492
  • Mass (Da)
    55,149
  • Last updated
    2013-12-11 v1
  • MD5 Checksum
    50EC1DF5FA95083327235F1E6AA384B8
MYLFQILAVLLVASCGWAKEEDVLEFGDSDFESGLTEHETALVMFYAPWCGHCKRLKPEFAKAAEDLLRNDPPVALVKVDCTEAGKETCNKNSVSGYPTLKIFRNGEYSQDYNGPREAAGLVKYMKAQVGPASKELKSVADLDKLLATEKESVVVGFFEKESDLKAAFLQLANKLREKVQFAHSSFKDVLEKQGETDAVVLFRPAHLKNKFEASSVKYSGPAETPDLNDFITKNFYGLVGVRKSDNQREFKNPLVVVYYAVDYVKNPKGTNYWRNRVLKVAKDFEGKINFAIASSDEFTHELNEFGIEYAPADKPRVAAKDADDKKYVLRDEFSPFALEAFVNDILDGQLDPYIKSEAIPESQEGPVVVAVAKNFDEVVINNGKDTLIEFYAPWCGHCKKLTPVYDELAEKLKDEEVSIVKLDATANDVSAPFDVKGFPTLYWAPKDKKDSPVRYDGGRTVDDFIKFIAKEATNELKGWDRDGNTKSAKTEL

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KB631792
EMBL· GenBank· DDBJ
ERL86146.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
Help