U4PM84 · U4PM84_CAEEL

  • Protein
    Phosphodiesterase
  • Gene
    pde-3
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    2/5

Function

Cofactor

a divalent metal cation (UniProtKB | Rhea| CHEBI:60240 )

Note: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

Features

Showing features for active site, binding site.

159350100150200250300350400450500550
Type
IDPosition(s)Description
Active site256Proton donor
Binding site256-260AMP (UniProtKB | ChEBI)
Binding site260Zn2+ 1 (UniProtKB | ChEBI)
Binding site321Zn2+ 1 (UniProtKB | ChEBI)
Binding site322AMP (UniProtKB | ChEBI)
Binding site322Zn2+ 1 (UniProtKB | ChEBI)
Binding site322Zn2+ 2 (UniProtKB | ChEBI)
Binding site431AMP (UniProtKB | ChEBI)
Binding site431Zn2+ 1 (UniProtKB | ChEBI)
Binding site482AMP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Function3',5'-cGMP-inhibited cyclic-nucleotide phosphodiesterase activity
Molecular Function3',5'-cGMP-stimulated cyclic-nucleotide phosphodiesterase activity
Molecular Functionmetal ion binding
Biological Processsignal transduction

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phosphodiesterase
  • EC number

Gene names

    • Name
      pde-3
    • ORF names
      CELE_E01F3.1
      , E01F3.1

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Bristol N2
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Nematoda > Chromadorea > Rhabditida > Rhabditina > Rhabditomorpha > Rhabditoidea > Rhabditidae > Peloderinae > Caenorhabditis

Accessions

  • Primary accession
    U4PM84

Proteomes

Organism-specific databases

Expression

Gene expression databases

Structure

Family & Domains

Features

Showing features for region, domain.

Type
IDPosition(s)Description
Region123-150Disordered
Domain181-532PDEase
Region555-575Disordered

Sequence similarities

Belongs to the cyclic nucleotide phosphodiesterase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    593
  • Mass (Da)
    66,830
  • Last updated
    2013-12-11 v1
  • Checksum
    2337DA1989F5BE07
MSDGHMQRTFHEAMRQRRTSLPANSLSLNGAKVTGSSLSEAKGLIADMLMNKELPGNVASCLRAVTMLLEQRPLPLNGLLNDFGLPSVVENPYGGESMVVGASKPRISNITFSTVTSATGLPTVPAEPNKARSSSYWKTEASPSNNNEHETPVDLLRKISVSRKESGTHVDTVVTTIDGQRYDTRELDTDPDLAETAVWSFPIFQMSRKHPQTILSRLTYNIFQQAELFRIFKVSPIKFFNFFHALEKGYWEIPYHNRIHAADVLHGCYYLSAHPVRSTFLTPKTPDSVLTPPHPHHQHSSIMSQLSTLELMALFTAAAMHDYDHPGRTNAFLVQVEDKKAILYNDRSVLENHHAAESWKLLNKPENHFIENLDPAEMKRFRYLVLEYILATDLKQHFEIIMTFTERLTEIDVQVETDRLLIGKLLIKMADINSPTKPYGLHRQWTDRICEEFYEQGDDERRRGLPITPYMDRGDAQVAKLQDSFIAHVVSPLATAMNECGLLPILPGLDTSELIINMEHNHRKWKEQIELENGGSYEAQITCNGGTAVNGVIEEESASTSDSPDPRRDSPLDSDLSQVPFTICCSIAEEEYV

Computationally mapped potential isoform sequences

There are 5 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
Q8I0P7PDE3_CAEELpde-3678
U4PBF4U4PBF4_CAEELpde-3640
U4PBS8U4PBS8_CAEELpde-3578
U4PEM9U4PEM9_CAEELpde-3693
U4PRI1U4PRI1_CAEELpde-3574

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BX284602
EMBL· GenBank· DDBJ
CDH93184.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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