U4PM84 · U4PM84_CAEEL
- ProteinPhosphodiesterase
- Genepde-3
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids593 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score2/5
Function
Cofactor
Note: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.
Features
Showing features for active site, binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Active site | 256 | Proton donor | |||
Binding site | 256-260 | AMP (UniProtKB | ChEBI) | |||
Binding site | 260 | Zn2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 321 | Zn2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 322 | AMP (UniProtKB | ChEBI) | |||
Binding site | 322 | Zn2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 322 | Zn2+ 2 (UniProtKB | ChEBI) | |||
Binding site | 431 | AMP (UniProtKB | ChEBI) | |||
Binding site | 431 | Zn2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 482 | AMP (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | 3',5'-cGMP-inhibited cyclic-nucleotide phosphodiesterase activity | |
Molecular Function | 3',5'-cGMP-stimulated cyclic-nucleotide phosphodiesterase activity | |
Molecular Function | metal ion binding | |
Biological Process | signal transduction |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePhosphodiesterase
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Nematoda > Chromadorea > Rhabditida > Rhabditina > Rhabditomorpha > Rhabditoidea > Rhabditidae > Peloderinae > Caenorhabditis
Accessions
- Primary accessionU4PM84
Proteomes
Organism-specific databases
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for region, domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 123-150 | Disordered | |||
Domain | 181-532 | PDEase | |||
Region | 555-575 | Disordered | |||
Sequence similarities
Belongs to the cyclic nucleotide phosphodiesterase family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length593
- Mass (Da)66,830
- Last updated2013-12-11 v1
- Checksum2337DA1989F5BE07
Computationally mapped potential isoform sequences
There are 5 potential isoforms mapped to this entry
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
BX284602 EMBL· GenBank· DDBJ | CDH93184.1 EMBL· GenBank· DDBJ | Genomic DNA |