U4PBK1 · U4PBK1_CAEEL
- ProteinHECT-type E3 ubiquitin transferase
- Geneeel-1
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids4183 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
Catalytic activity
Pathway
Protein modification; protein ubiquitination.
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 4150 | Glycyl thioester intermediate | ||||
Sequence: C |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | nucleus | |
Molecular Function | ubiquitin protein ligase activity | |
Biological Process | protein polyubiquitination | |
Biological Process | ubiquitin-dependent protein catabolic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameHECT-type E3 ubiquitin transferase
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Nematoda > Chromadorea > Rhabditida > Rhabditina > Rhabditomorpha > Rhabditoidea > Rhabditidae > Peloderinae > Caenorhabditis
Accessions
- Primary accessionU4PBK1
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Expression
Gene expression databases
Family & Domains
Features
Showing features for region, compositional bias, domain, coiled coil.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-20 | Disordered | ||||
Sequence: MKIDDAEPSSSSSGSDMPPA | ||||||
Compositional bias | 491-515 | Acidic residues | ||||
Sequence: FEEEPEPRDDQEAHEEPEDESDERN | ||||||
Region | 491-560 | Disordered | ||||
Sequence: FEEEPEPRDDQEAHEEPEDESDERNPVDQEAPVPIEVDAPLPPASPIAAPAPVPVASASTSSDSKIKGGP | ||||||
Compositional bias | 526-540 | Pro residues | ||||
Sequence: EVDAPLPPASPIAAP | ||||||
Region | 808-866 | Disordered | ||||
Sequence: LQREIPEQADERVGGDVEEEPMEVEDAEDSDVDEEDNEMSMDEMSGEAPAPPAAPSPKP | ||||||
Compositional bias | 820-849 | Acidic residues | ||||
Sequence: VGGDVEEEPMEVEDAEDSDVDEEDNEMSMD | ||||||
Region | 1118-1139 | Disordered | ||||
Sequence: WDEDSVDEQQKRDEAKEPRWKA | ||||||
Domain | 1434-1473 | UBA | ||||
Sequence: DPHEDTIVMLMDLGFSRDIVLYALESTRNADEAANYLLAH | ||||||
Region | 2032-2063 | Disordered | ||||
Sequence: SVSSTAGGASTSSSSAPPPPPPLTSSSSHTVV | ||||||
Coiled coil | 2177-2216 | |||||
Sequence: LASYSEKASELRVDLAKLQLDKESEEREEATTSLKKQETE | ||||||
Region | 2371-2553 | Disordered | ||||
Sequence: RGNSVQRGAGQVAEEEEGSETYEERERSDSPSESSEHAGDEEVRDDAVETGDGEVDMADAQDAPLAAPDAPPGINLVDEIMQQVQRDVEDDEEDEDGDQNEHEAEEDDHDREDEDDEDDDDDEDEEEEAEDDDQDEDDVRHVEQNPEPLARRLFEEDDDDEEDDDGDEDGDSMEDDVQRLDLD | ||||||
Compositional bias | 2393-2414 | Basic and acidic residues | ||||
Sequence: EERERSDSPSESSEHAGDEEVR | ||||||
Compositional bias | 2455-2508 | Acidic residues | ||||
Sequence: QRDVEDDEEDEDGDQNEHEAEEDDHDREDEDDEDDDDDEDEEEEAEDDDQDEDD | ||||||
Compositional bias | 2509-2523 | Basic and acidic residues | ||||
Sequence: VRHVEQNPEPLARRL | ||||||
Compositional bias | 2524-2552 | Acidic residues | ||||
Sequence: FEEDDDDEEDDDGDEDGDSMEDDVQRLDL | ||||||
Compositional bias | 2800-2814 | Basic and acidic residues | ||||
Sequence: EAAKKAAEDKKKAAE | ||||||
Region | 2800-2945 | Disordered | ||||
Sequence: EAAKKAAEDKKKAAEAPAPAPSAEQSDSPASPDAPAPAPEEIGLATPAATNTTNTVSESVAPNASTRGDDTLTTPAAAQVEDQASEDQHIEEEPMEVGEDDGAAEAPQSSAATAASSVAGTEEIEDVERQAVEDHVPEIQDNDDTL | ||||||
Compositional bias | 2845-2880 | Polar residues | ||||
Sequence: TPAATNTTNTVSESVAPNASTRGDDTLTTPAAAQVE | ||||||
Compositional bias | 2885-2899 | Acidic residues | ||||
Sequence: EDQHIEEEPMEVGED | ||||||
Compositional bias | 2921-2941 | Basic and acidic residues | ||||
Sequence: EEIEDVERQAVEDHVPEIQDN | ||||||
Region | 3004-3040 | Disordered | ||||
Sequence: QQRAERASRPVPAAQPVAVNPNAPAGGEAAQGEGQAE | ||||||
Region | 3595-3663 | Disordered | ||||
Sequence: IRKDKAKRAKDAEKKLKEKETPSTSAPAAPAAPATAPTAPAAPDAPVENNEVPEPAAELEEVNDEEPRI | ||||||
Compositional bias | 3599-3615 | Basic and acidic residues | ||||
Sequence: KAKRAKDAEKKLKEKET | ||||||
Region | 3716-3735 | Disordered | ||||
Sequence: AKDAEAKRKESQAASSSAAA | ||||||
Domain | 3847-4183 | HECT | ||||
Sequence: RPSEWKNRFYIIFQGEEGQDAGGLLREWFSVITREIFNPNYALFITAPGDMVTYMINKASYINPEHLDYFKFVGRLIAKSVFEHKYLDCYFTRAFYKHILNLPVRYQDLESEDPAFFKSLDFLLQNPIDDLALDLTFSTEVEEFGVRSVRDLKPNGRKIEVNDANKDEYVKLVCQMKMTGSIRKQLDAFLTGFYEIIPKDLISMFNEQELELLISGLPTVDIDDMAANTDYKGFQKTSTHIQWFWRALRSFEKEDKAKFLQFVTGTSKVPLQGFASLEGMNGVQKFSIHMDSRGGDRLPAAHTCFNQLDLPQYESYEKLRQSLLLAIRECTEGFGFA |
Sequence similarities
Belongs to the UPL family. TOM1/PTR1 subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length4,183
- Mass (Da)466,159
- Last updated2013-12-11 v1
- ChecksumF711B23BE49D4B7C
Computationally mapped potential isoform sequences
There are 7 potential isoforms mapped to this entry
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 491-515 | Acidic residues | ||||
Sequence: FEEEPEPRDDQEAHEEPEDESDERN | ||||||
Compositional bias | 526-540 | Pro residues | ||||
Sequence: EVDAPLPPASPIAAP | ||||||
Compositional bias | 820-849 | Acidic residues | ||||
Sequence: VGGDVEEEPMEVEDAEDSDVDEEDNEMSMD | ||||||
Compositional bias | 2393-2414 | Basic and acidic residues | ||||
Sequence: EERERSDSPSESSEHAGDEEVR | ||||||
Compositional bias | 2455-2508 | Acidic residues | ||||
Sequence: QRDVEDDEEDEDGDQNEHEAEEDDHDREDEDDEDDDDDEDEEEEAEDDDQDEDD | ||||||
Compositional bias | 2509-2523 | Basic and acidic residues | ||||
Sequence: VRHVEQNPEPLARRL | ||||||
Compositional bias | 2524-2552 | Acidic residues | ||||
Sequence: FEEDDDDEEDDDGDEDGDSMEDDVQRLDL | ||||||
Compositional bias | 2800-2814 | Basic and acidic residues | ||||
Sequence: EAAKKAAEDKKKAAE | ||||||
Compositional bias | 2845-2880 | Polar residues | ||||
Sequence: TPAATNTTNTVSESVAPNASTRGDDTLTTPAAAQVE | ||||||
Compositional bias | 2885-2899 | Acidic residues | ||||
Sequence: EDQHIEEEPMEVGED | ||||||
Compositional bias | 2921-2941 | Basic and acidic residues | ||||
Sequence: EEIEDVERQAVEDHVPEIQDN | ||||||
Compositional bias | 3599-3615 | Basic and acidic residues | ||||
Sequence: KAKRAKDAEKKLKEKET |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
BX284604 EMBL· GenBank· DDBJ | CDH93243.1 EMBL· GenBank· DDBJ | Genomic DNA |