U4PBK1 · U4PBK1_CAEEL

  • Protein
    HECT-type E3 ubiquitin transferase
  • Gene
    eel-1
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    3/5

Function

Catalytic activity

  • S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N6-ubiquitinyl-[acceptor protein]-L-lysine.
    EC:2.3.2.26 (UniProtKB | ENZYME | Rhea)

Pathway

Protein modification; protein ubiquitination.

Features

Showing features for active site.

141835001,0001,5002,0002,5003,0003,5004,000
TypeIDPosition(s)Description
Active site4150Glycyl thioester intermediate

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentnucleus
Molecular Functionubiquitin protein ligase activity
Biological Processprotein polyubiquitination
Biological Processubiquitin-dependent protein catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    HECT-type E3 ubiquitin transferase
  • EC number

Gene names

    • Name
      eel-1
    • ORF names
      CELE_Y67D8C.5
      , Y67D8C.5

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Bristol N2
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Nematoda > Chromadorea > Rhabditida > Rhabditina > Rhabditomorpha > Rhabditoidea > Rhabditidae > Peloderinae > Caenorhabditis

Accessions

  • Primary accession
    U4PBK1

Proteomes

Organism-specific databases

Subcellular Location

PTM/Processing

Keywords

Proteomic databases

Expression

Gene expression databases

Structure

3D structure databases

Family & Domains

Features

Showing features for region, compositional bias, domain, coiled coil.

TypeIDPosition(s)Description
Region1-20Disordered
Compositional bias491-515Acidic residues
Region491-560Disordered
Compositional bias526-540Pro residues
Region808-866Disordered
Compositional bias820-849Acidic residues
Region1118-1139Disordered
Domain1434-1473UBA
Region2032-2063Disordered
Coiled coil2177-2216
Region2371-2553Disordered
Compositional bias2393-2414Basic and acidic residues
Compositional bias2455-2508Acidic residues
Compositional bias2509-2523Basic and acidic residues
Compositional bias2524-2552Acidic residues
Compositional bias2800-2814Basic and acidic residues
Region2800-2945Disordered
Compositional bias2845-2880Polar residues
Compositional bias2885-2899Acidic residues
Compositional bias2921-2941Basic and acidic residues
Region3004-3040Disordered
Region3595-3663Disordered
Compositional bias3599-3615Basic and acidic residues
Region3716-3735Disordered
Domain3847-4183HECT

Sequence similarities

Belongs to the UPL family. TOM1/PTR1 subfamily.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    4,183
  • Mass (Da)
    466,159
  • Last updated
    2013-12-11 v1
  • Checksum
    F711B23BE49D4B7C

Computationally mapped potential isoform sequences

There are 7 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
U4PBY0U4PBY0_CAEELeel-14185
U4PBJ5U4PBJ5_CAEELeel-14179
U4PBX5U4PBX5_CAEELeel-14180
U4PES6U4PES6_CAEELeel-14182
Q9GUP2Q9GUP2_CAEELeel-14177
U4PRN6U4PRN6_CAEELeel-14180
U4PMD1U4PMD1_CAEELeel-14182

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias491-515Acidic residues
Compositional bias526-540Pro residues
Compositional bias820-849Acidic residues
Compositional bias2393-2414Basic and acidic residues
Compositional bias2455-2508Acidic residues
Compositional bias2509-2523Basic and acidic residues
Compositional bias2524-2552Acidic residues
Compositional bias2800-2814Basic and acidic residues
Compositional bias2845-2880Polar residues
Compositional bias2885-2899Acidic residues
Compositional bias2921-2941Basic and acidic residues
Compositional bias3599-3615Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BX284604
EMBL· GenBank· DDBJ
CDH93243.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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