U3REG5 · U3REG5_9DELA

Function

function

Binds strongly to viral nucleic acids and promote their aggregation. Also destabilizes the nucleic acids duplexes via highly structured zinc-binding motifs.
Forms the spherical core of the virus that encapsulates the genomic RNA-nucleocapsid complex.
Matrix protein.
The matrix domain targets Gag, Gag-Pro and Gag-Pro-Pol polyproteins to the plasma membrane via a multipartite membrane binding signal, that includes its myristoylated N-terminus.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentviral nucleocapsid
Molecular Functionnucleic acid binding
Molecular Functionstructural molecule activity
Molecular Functionzinc ion binding
Biological Processviral process

Keywords

Names & Taxonomy

Protein names

  • Submitted names
    • Gag

Organism names

  • Taxonomic identifier
  • Strains
    • Aus-DM
    • Aus-LT
    • Aus-PS
  • Taxonomic lineage
    Viruses > Riboviria > Pararnavirae > Artverviricota > Revtraviricetes > Ortervirales > Retroviridae > Orthoretrovirinae > Deltaretrovirus > Primate T-lymphotropic virus 1

Accessions

  • Primary accession
    U3REG5

Subcellular Location

Keywords

PTM/Processing

Keywords

Interaction

Subunit

Homodimer; further assembles as homohexamers.
Homodimer; the homodimers are part of the immature particles. Interacts with human TSG101 and NEDD4; these interactions are essential for budding and release of viral particles.

Family & Domains

Features

Showing features for region, compositional bias, domain.

TypeIDPosition(s)Description
Region93-142Disordered
Compositional bias95-126Pro residues
Domain357-372CCHC-type
Region392-429Disordered

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    429
  • Mass (Da)
    47,631
  • Last updated
    2013-12-11 v1
  • Checksum
    C9BE2B9056B24083
MGQIFPRSANPIPRPPRGLAAHHWLNFLQAAYRLEPGPSSYDFHQLKQFLKMALETPVWMCPINYSLLASLLPKGYPGRVNEILHILIQTQTQIPSHPAPPPPSSPTHDPSDSNPQIPPPYVEPTAPQVLPVMHPHGVPPSHRPWQMKDLQAIKQEVSQAAPGSPQFMQTIRLAVQQFDPTAKDLQDLLQYLCSSLVASLHHQQLDSLISEAETRGITGYNPLAGPLRVQANNPQQQGLRREYQQLWLTAFAALPGSAKDPSWASILQGLEEPYHTFVERLNVALDNGLPEGTPKDPILRSLAYSNANKECQKLLQARGHTNSPLGDMLRACQAWTPKDKTKVLVVQPKKPPPNQPCFRCGKAGHWSRDCTQPRPPPGPCPLCQDPTHWKRDCPRLKPAVPEPEPEEDALLLDLPTDNPHPKNSIGGEV

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias95-126Pro residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KC786928
EMBL· GenBank· DDBJ
AGX01637.1
EMBL· GenBank· DDBJ
Genomic DNA
KC786937
EMBL· GenBank· DDBJ
AGX01646.1
EMBL· GenBank· DDBJ
Genomic DNA
KC786939
EMBL· GenBank· DDBJ
AGX01648.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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