U3M1T9 · U3M1T9_9APIC

  • Protein
    Bifunctional dihydrofolate reductase-thymidylate synthase
  • Gene
    dhfr-ts
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, DNA precursor synthesis, and for the conversion of dUMP to dTMP.

Catalytic activity

Pathway

Cofactor biosynthesis; tetrahydrofolate biosynthesis; 5,6,7,8-tetrahydrofolate from 7,8-dihydrofolate: step 1/1.

Features

Showing features for active site.

TypeIDPosition(s)Description
Active site477

GO annotations

AspectTerm
Cellular Componentcytosol
Cellular Componentmitochondrion
Molecular Functiondihydrofolate reductase activity
Molecular Functionthymidylate synthase activity
Biological ProcessdTMP biosynthetic process
Biological Processmethylation
Biological Processone-carbon metabolic process
Biological Processtetrahydrofolate biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Bifunctional dihydrofolate reductase-thymidylate synthase
  • EC number

Gene names

    • Name
      dhfr-ts

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Sar > Alveolata > Apicomplexa > Aconoidasida > Haemosporida > Plasmodiidae > Plasmodium > Plasmodium (Laverania)

Accessions

  • Primary accession
    U3M1T9

Organism-specific databases

Subcellular Location

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-216DHFR

Sequence similarities

In the C-terminal section; belongs to the thymidylate synthase family.
In the N-terminal section; belongs to the dihydrofolate reductase family.

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    593
  • Mass (Da)
    69,886
  • Last updated
    2013-12-11 v1
  • MD5 Checksum
    AA9413577F3E0443271A8E981FB7641B
AICACCKVENKNEVKKNEVFNNYTFRGLGNKGVLPWKCNSLDMKYFCAVTTYVNESKYEKLKYKRCKYLNKETPNNVMDMPNSKKLQNVVVMGRTSWESIPKKFKPLSNRINVILSRTLKKEDFDEDVYIINKVEDLIVLLGKLNYYKCFIIGGSVVYKEFLEKKLIKKIYFTRINSSYECDVFFPEINENEYQIISVSDVYTSNNTTLDFVIYKKKNNQVLNEKDCIKGEEKNNDMSLKNDDKVTCHMKKLTEFYKNVDKYKINYENDDDDEEXDFVYFNFNKEKEEKNKNCVHPNDFQIYNSLKHKCHPEYQYLNIIYDIIMNGNKQSDRTGVGVLSKFGYIMKFDLSQYFPLLTTKKLFLRGIIEELLWFIRGETNGNTLLNKNVRIWEANGTREFLDNRKLFHREVNDLGPIYGFQWRHFGAEYTNMHDNYENKGVDQLKNIINLIKNDPTSRRILLCAWNVKDLDQMALPPCHILCQFYVFDGKLSCIMYQRSCDLGLGVPFNIASYSIFTHMIAQVCNLQPAEFIHVLGNAHVYNNHIDSLKIQLNRIPYPFPTLKLNPDIKNIEDFTISDFTIQNYVHHEKISMDM

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue593

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JX893168
EMBL· GenBank· DDBJ
AGR88695.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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