U3E9X5 · U3E9X5_CALJA
- ProteinAcyl-coenzyme A oxidase
- GeneACOX1
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids661 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score4/5
Function
function
Involved in the initial and rate-limiting step of peroxisomal beta-oxidation of straight-chain saturated and unsaturated very-long-chain fatty acids. Catalyzes the desaturation of fatty acyl-CoAs such as palmitoyl-CoA (hexadecanoyl-CoA) to 2-trans-enoyl-CoAs ((2E)-enoyl-CoAs) such as (2E)-hexadecenoyl-CoA, and donates electrons directly to molecular oxygen (O2), thereby producing hydrogen peroxide (H2O2).
Catalytic activity
- (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + O2 = (2E,5Z,8Z,11Z,14Z,17Z)-icosahexaenoyl-CoA + H2O2This reaction proceeds in the forward direction.
- (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + O2 = (2E,6Z,9Z,12Z,15Z,18Z,21Z)-tetracosaheptaenoyl-CoA + H2O2This reaction proceeds in the forward direction.
- octadecanoyl-CoA + O2 = (2E)-octadecenoyl-CoA + H2O2This reaction proceeds in the forward direction.
- octanoyl-CoA + O2 = (2E)-octenoyl-CoA + H2O2This reaction proceeds in the forward direction.
- tetracosanoyl-CoA + O2 = (2E)-tetracosenoyl-CoA + H2O2This reaction proceeds in the forward direction.
- tetradecanoyl-CoA + O2 = (2E)-tetradecenoyl-CoA + H2O2This reaction proceeds in the forward direction.
- decanoyl-CoA + O2 = (2E)-decenoyl-CoA + H2O2This reaction proceeds in the forward direction.
- dodecanoyl-CoA + O2 = (2E)-dodecenoyl-CoA + H2O2This reaction proceeds in the forward direction.
- glutaryl-CoA + O2 = (2E)-glutaconyl-CoA + H2O2This reaction proceeds in the forward direction.
- hexadecanedioyl-CoA + O2 = (2E)-hexadecenedioyl-CoA + H2O2This reaction proceeds in the forward direction.
- hexadecanoyl-CoA + O2 = (2E)-hexadecenoyl-CoA + H2O2This reaction proceeds in the forward direction.
- hexanoyl-CoA + O2 = (2E)-hexenoyl-CoA + H2O2This reaction proceeds in the forward direction.
Cofactor
Pathway
Lipid metabolism; peroxisomal fatty acid beta-oxidation.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 139 | FAD (UniProtKB | ChEBI) | |||
Binding site | 178 | FAD (UniProtKB | ChEBI) | |||
Active site | 421 | Proton acceptor | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | peroxisome | |
Molecular Function | FAD binding | |
Molecular Function | fatty acid binding | |
Molecular Function | palmitoyl-CoA oxidase activity | |
Biological Process | fatty acid beta-oxidation using acyl-CoA oxidase | |
Biological Process | lipid homeostasis | |
Biological Process | very long-chain fatty acid metabolic process |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameAcyl-coenzyme A oxidase
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Platyrrhini > Cebidae > Callitrichinae > Callithrix > Callithrix
Accessions
- Primary accessionU3E9X5
- Secondary accessions
Proteomes
Subcellular Location
PTM/Processing
Keywords
- PTM
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 15-133 | Acyl-coenzyme A oxidase N-terminal | |||
Domain | 136-244 | Acyl-CoA oxidase/dehydrogenase middle | |||
Domain | 275-436 | Acyl-CoA oxidase C-alpha1 | |||
Domain | 480-657 | Acyl-CoA oxidase C-terminal | |||
Sequence similarities
Belongs to the acyl-CoA oxidase family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length661
- Mass (Da)74,822
- Last updated2013-11-13 v1
- ChecksumB1297B9652717A82
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
U3D524 | U3D524_CALJA | ACOX1 | 661 |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
GAMT01007050 EMBL· GenBank· DDBJ | JAB04811.1 EMBL· GenBank· DDBJ | mRNA | ||
GAMS01003111 EMBL· GenBank· DDBJ | JAB20025.1 EMBL· GenBank· DDBJ | mRNA | ||
GAMR01000094 EMBL· GenBank· DDBJ | JAB33838.1 EMBL· GenBank· DDBJ | mRNA | ||
GAMR01000084 EMBL· GenBank· DDBJ | JAB33848.1 EMBL· GenBank· DDBJ | mRNA | ||
GAMQ01002872 EMBL· GenBank· DDBJ | JAB38979.1 EMBL· GenBank· DDBJ | mRNA | ||
GAMP01006443 EMBL· GenBank· DDBJ | JAB46312.1 EMBL· GenBank· DDBJ | mRNA |