U3E7R5 · U3E7R5_CALJA
- ProteinPhosphodiesterase
- GenePDE1C
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids634 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
Catalytic activity
- 3',5'-cyclic AMP + H2O = AMP + H+This reaction proceeds in the forward direction.
- 3',5'-cyclic GMP + H2O = GMP + H+This reaction proceeds in the forward direction.
Cofactor
Note: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.
Features
Showing features for active site, binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Active site | 228 | Proton donor | |||
Binding site | 228-232 | AMP (UniProtKB | ChEBI) | |||
Binding site | 232 | Zn2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 268 | Zn2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 269 | AMP (UniProtKB | ChEBI) | |||
Binding site | 269 | Zn2+ 2 (UniProtKB | ChEBI) | |||
Binding site | 269 | Zn2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 376 | AMP (UniProtKB | ChEBI) | |||
Binding site | 376 | Zn2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 427 | AMP (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | neuronal cell body | |
Molecular Function | calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity | |
Molecular Function | metal ion binding | |
Biological Process | signal transduction |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePhosphodiesterase
- EC number
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Platyrrhini > Cebidae > Callitrichinae > Callithrix > Callithrix
Accessions
- Primary accessionU3E7R5
Subcellular Location
UniProt Annotation
GO Annotation
Structure
Family & Domains
Features
Showing features for coiled coil, domain, compositional bias, region.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Coiled coil | 34-64 | ||||
Domain | 151-528 | PDEase | |||
Compositional bias | 456-495 | Polar residues | |||
Region | 456-497 | Disordered | |||
Compositional bias | 523-570 | Basic and acidic residues | |||
Region | 523-634 | Disordered | |||
Compositional bias | 583-597 | Basic and acidic residues | |||
Compositional bias | 609-634 | Basic and acidic residues | |||
Sequence similarities
Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length634
- Mass (Da)72,317
- Last updated2013-11-13 v1
- Checksum6D9405B7F4FD63C9
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 456-495 | Polar residues | |||
Compositional bias | 523-570 | Basic and acidic residues | |||
Compositional bias | 583-597 | Basic and acidic residues | |||
Compositional bias | 609-634 | Basic and acidic residues | |||
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
GAMS01004442 EMBL· GenBank· DDBJ | JAB18694.1 EMBL· GenBank· DDBJ | mRNA | ||
GAMR01004229 EMBL· GenBank· DDBJ | JAB29703.1 EMBL· GenBank· DDBJ | mRNA | ||
GAMQ01003617 EMBL· GenBank· DDBJ | JAB38234.1 EMBL· GenBank· DDBJ | mRNA | ||
GAMP01007550 EMBL· GenBank· DDBJ | JAB45205.1 EMBL· GenBank· DDBJ | mRNA |