U2TJP8 · U2TJP8_STRPY

Function

function

Catalyzes the reversible phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Features

Showing features for binding site, active site, site.

TypeIDPosition(s)Description
Binding site4a purine D-ribonucleoside (UniProtKB | ChEBI); ligand shared between dimeric partners
Binding site20phosphate (UniProtKB | ChEBI); ligand shared between dimeric partners; in other chain
Binding site24phosphate (UniProtKB | ChEBI); ligand shared between dimeric partners; in other chain
Binding site43phosphate (UniProtKB | ChEBI); ligand shared between dimeric partners
Binding site87-90phosphate (UniProtKB | ChEBI); ligand shared between dimeric partners; in other chain
Binding site179-181a purine D-ribonucleoside (UniProtKB | ChEBI); ligand shared between dimeric partners; in other chain
Binding site203-204a purine D-ribonucleoside (UniProtKB | ChEBI); ligand shared between dimeric partners; in other chain
Active site204Proton donor
Site218Important for catalytic activity

GO annotations

AspectTerm
Molecular Functionpurine-nucleoside phosphorylase activity
Molecular Functionuridine phosphorylase activity
Biological Processnucleoside catabolic process
Biological Processpurine nucleoside metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Purine nucleoside phosphorylase DeoD-type
  • EC number
  • Short names
    PNP

Gene names

    • Name
      deoD
    • ORF names
      HMPREF1231_1255

Organism names

Accessions

  • Primary accession
    U2TJP8

Proteomes

Interaction

Subunit

Homohexamer; trimer of homodimers.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain16-222Nucleoside phosphorylase

Sequence similarities

Belongs to the PNP/UDP phosphorylase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    237
  • Mass (Da)
    26,034
  • Last updated
    2013-11-13 v1
  • Checksum
    09667EF0A34732E8
MSIHISAKKGDIADKILLPGDPLRAKFIAENFLEDAVCFNEVRNMFGYTGTYKGHRVSVMGTGMGMPSISIYARELIVDYGVKTLIRVGTAGAIDPEVHVRELVLAQAAATNSNIIRNDFPEFDFPQIADFGLLDKAYHIAREMGVTTHVGNVLSSDVFYTNMPERNMALGKLGVKAIEMEAAALYYLAAQHHVKALGIMTISDNLNDPTEDTTAEERQTTFTDMMKIGLETLIAND

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AWPJ01000415
EMBL· GenBank· DDBJ
ERL06695.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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