U2NV54 · U2NV54_LEVBR

Function

function

Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
FMN (UniProtKB | Rhea| CHEBI:58210 )

Note: Binds 1 FMN per subunit.
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Pathway

Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 2/5.
Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 3/5.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site279CTP (UniProtKB | ChEBI)
Binding site289CTP (UniProtKB | ChEBI)
Binding site307-310CTP (UniProtKB | ChEBI)
Binding site326CTP (UniProtKB | ChEBI)
Binding site340CTP (UniProtKB | ChEBI)
Binding site344CTP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentphosphopantothenoylcysteine decarboxylase complex
Molecular FunctionFMN binding
Molecular Functionmetal ion binding
Molecular Functionphosphopantothenate--cysteine ligase activity
Molecular Functionphosphopantothenoylcysteine decarboxylase activity
Biological Processcoenzyme A biosynthetic process
Biological Processpantothenate catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Coenzyme A biosynthesis bifunctional protein CoaBC
  • Alternative names
    • DNA/pantothenate metabolism flavoprotein
    • Phosphopantothenoylcysteine synthetase/decarboxylase
      (PPCS-PPCDC
      )

Including 2 domains:

  • Recommended name
    Phosphopantothenoylcysteine decarboxylase
  • EC number
  • Short names
    PPC decarboxylase
    ; PPC-DC
  • Alternative names
    • CoaC
  • Recommended name
    Phosphopantothenate--cysteine ligase
  • EC number
  • Alternative names
    • CoaB
    • Phosphopantothenoylcysteine synthetase
      (PPC synthetase
      ; PPC-S
      )

Gene names

    • Name
      coaBC
    • ORF names
      HMPREF0495_02046

Organism names

Accessions

  • Primary accession
    U2NV54

Proteomes

Family & Domains

Features

Showing features for region, domain.

TypeIDPosition(s)Description
Region1-190Phosphopantothenoylcysteine decarboxylase
Domain5-177Flavoprotein
Domain186-371DNA/pantothenate metabolism flavoprotein C-terminal
Region191-403Phosphopantothenate--cysteine ligase

Sequence similarities

In the C-terminal section; belongs to the PPC synthetase family.
In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    403
  • Mass (Da)
    42,622
  • Last updated
    2013-11-13 v1
  • Checksum
    24769295AEE56B12
MFEGKHITLIVSGSVASYKAATLARELQRAGAQVRVILTTGAAQFVTAATFAALTKTTVLTDDNWWQADGQIRHIEWADWTDLLIAAPASANLMAQLANGLANDAASATWLATAAPKVVVPAMNTHMWQAPATQRNRQQLMTDGVHVLTPATGVLAEGYSGQGRFLAPAEIVRQLADLPLFTPQTLAGKRVIVTAGGTRERLDPVRFLTNDSSGKMGYAVAAAAQQAGAKVTLITAPTGLSAPSGVDIVNIQSTTELATAVLDRFPNADVLVMAAAVADFQPVTVADQKIKKTADNDEMVLTLKKTPDILKQVAAIKQPHQVTVGFAAETQAVLANGQKKLADKQLDLLAANDVSRQDIGFNSDDNQVTFIMPDGVTDQTPKTSKRVIAQALVSRVATILAAK

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AWVK01000096
EMBL· GenBank· DDBJ
ERK41915.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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