U1N7F0 · U1N7F0_9BACL

Function

function

Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
K+ (UniProtKB | Rhea| CHEBI:29103 )

Note: Binds 1 potassium ion per subunit.
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site53-57(6S)-NADPHX (UniProtKB | ChEBI)
Binding site54K+ (UniProtKB | ChEBI)
Binding site111K+ (UniProtKB | ChEBI)
Binding site115-121(6S)-NADPHX (UniProtKB | ChEBI)
Binding site144(6S)-NADPHX (UniProtKB | ChEBI)
Binding site147K+ (UniProtKB | ChEBI)
Binding site241(6S)-NADPHX (UniProtKB | ChEBI)
Binding site296(6S)-NADPHX (UniProtKB | ChEBI)
Binding site340(6S)-NADPHX (UniProtKB | ChEBI)
Binding site377-381AMP (UniProtKB | ChEBI)
Binding site406AMP (UniProtKB | ChEBI)
Binding site407(6S)-NADPHX (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular FunctionADP-dependent NAD(P)H-hydrate dehydratase activity
Molecular FunctionATP binding
Molecular Functionmetal ion binding
Molecular FunctionNADHX epimerase activity
Molecular FunctionNADPHX epimerase activity
Biological Processmetabolite repair
Biological Processnicotinamide nucleotide metabolic process

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Bifunctional NAD(P)H-hydrate repair enzyme
  • Alternative names
    • Nicotinamide nucleotide repair protein

Including 2 domains:

  • Recommended name
    ADP-dependent (S)-NAD(P)H-hydrate dehydratase
  • EC number
  • Alternative names
    • ADP-dependent NAD(P)HX dehydratase
  • Recommended name
    NAD(P)H-hydrate epimerase
  • EC number

Gene names

    • Name
      nnrD
    • Synonyms
      nnrE
    • ORF names
      M467_14320

Organism names

Accessions

  • Primary accession
    U1N7F0

Proteomes

Interaction

Subunit

Homotetramer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain8-202YjeF N-terminal
Domain206-465YjeF C-terminal

Sequence similarities

Belongs to the NnrD/CARKD family.
Belongs to the NnrE/AIBP family.
In the C-terminal section; belongs to the NnrD/CARKD family.
In the N-terminal section; belongs to the NnrE/AIBP family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    465
  • Mass (Da)
    49,985
  • Last updated
    2013-11-13 v1
  • Checksum
    9B2D5A5CD621EAF0
MIYTAAEIKQADATAFRQGMPADVLMERAASAVAARLTFRPRSSVLVICGAGNNGGDGWVVARESAQRGCDVFVYAPFGEPKSSEGERHAAYARRFVTIVEEPRDADYVVDALFGVGFRGPVTGKARDVITWMREQSAPVMAIDVPSGVPSDEASEFDGHAVKADTTFSLHGYKRSAFLTQTAPYYGTVEMVDIGLSHKSEWRVLTESDFDRGLLERDPYGHKNRYGHGCLIGGSRHLIGAPFLAARAALRTGIGLLDLAIPSEAHIMASSLPEAMYYGIDELPDKTYAATAIGPGLVDDERSDRLWQTVSRQSKPLIVDAGALTTEHLAAEGPLTLTPHPGEFARLTGRSVAEIEADRFRIASDFARQHGIHLILKGTHTLIVKPDGTGAVNTIQAAVLSKGGSGDVLTGMLLALWARTDRIDTESSPNEQAVLWHALAAQAASRQMHPASVLATDVIEAIGRI

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
ATCL01000009
EMBL· GenBank· DDBJ
ERG68450.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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