U1MZR8 · U1MZR8_9BACL

Function

function

Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N2-acetylornithine and glutamate.

Miscellaneous

Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Amino-acid biosynthesis; L-arginine biosynthesis; L-ornithine and N-acetyl-L-glutamate from L-glutamate and N2-acetyl-L-ornithine (cyclic): step 1/1.
Amino-acid biosynthesis; L-arginine biosynthesis; N2-acetyl-L-ornithine from L-glutamate: step 1/4.

Features

Showing features for site, binding site, active site.

TypeIDPosition(s)Description
Site118Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Site119Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Binding site155substrate
Binding site181substrate
Site191-192Cleavage; by autolysis
Active site192Nucleophile
Binding site192substrate
Binding site278substrate
Binding site400substrate
Binding site405substrate

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionacetyl-CoA:L-glutamate N-acetyltransferase activity
Molecular Functionglutamate N-acetyltransferase activity
Molecular Functionmethione N-acyltransferase activity
Biological Processarginine biosynthetic process
Biological Processornithine biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

Including 2 domains:

  • Recommended name
    Glutamate N-acetyltransferase
  • EC number
  • Alternative names
    • Ornithine acetyltransferase
      (OATase
      )
    • Ornithine transacetylase
  • Recommended name
    Amino-acid acetyltransferase
  • EC number
  • Alternative names
    • N-acetylglutamate synthase
      (AGSase
      )

Gene names

    • Name
      argJ
    • ORF names
      M467_01770

Organism names

Accessions

  • Primary accession
    U1MZR8

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_50232309751-191Arginine biosynthesis bifunctional protein ArgJ alpha chain
ChainPRO_5023230974192-405Arginine biosynthesis bifunctional protein ArgJ beta chain

Keywords

Interaction

Subunit

Heterotetramer of two alpha and two beta chains.

Protein-protein interaction databases

Family & Domains

Sequence similarities

Belongs to the ArgJ family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    405
  • Mass (Da)
    42,663
  • Last updated
    2013-11-13 v1
  • Checksum
    C55B265D960EB875
MIETTISPVVHVVTPKGFQACGVHAGLKRKRKDLALLVCEQLASAAAVYTTNQFQAAPIQVTKETLHASSGKIRAVLINSGNANACTGPQGLEDAYTMRDKAAEHIGVKPEEVAIASTGVIGQLLPMETLLNGIDLLEPIHEETGAESFAEAILTTDTGTKCTGVEYTEGGATVTIAGVAKGSGMIHPNMATMLGFITTDAVIAPDVLQRALKQSVDASFNSITVDGDSSTNDMVLALASGLTEMDEIIEGTPAYDCFCQALTDVCTDLAKAIARDGEGATKLIEVEVVGAKTDEAARMIAKQVVGSSLVKTAVYGQDANWGRIIAAIGASEQPIDVNHVDIRIGSQHVLMESAPVWFDEALATEEMGQDVVSIQIRLQDGTGQGQAYGCDLTYDYVKINASYRT

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
ATCL01000022
EMBL· GenBank· DDBJ
ERG65985.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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