U1MVJ6 · U1MVJ6_9MICO

Function

function

Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site26-31substrate
Active site86Proton acceptor
Binding site86Mg2+ (UniProtKB | ChEBI)
Binding site87substrate
Binding site165-168substrate
Binding site189substrate
Binding site194-195substrate

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctiondITP diphosphatase activity
Molecular FunctionITP diphosphatase activity
Molecular Functionmetal ion binding
Molecular Functionnucleotide binding
Molecular Functionribonucleoside triphosphate phosphatase activity
Molecular FunctionXTP diphosphatase activity
Biological Processnucleotide metabolic process
Biological Processpurine nucleoside triphosphate catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    dITP/XTP pyrophosphatase
  • EC number
  • Alternative names
    • Non-canonical purine NTP pyrophosphatase
    • Non-standard purine NTP pyrophosphatase
    • Nucleoside-triphosphate diphosphatase
    • Nucleoside-triphosphate pyrophosphatase
      (NTPase
      )

Gene names

    • ORF names
      L332_09445

Organism names

  • Taxonomic identifier
  • Strain
    • RW1
  • Taxonomic lineage
    Bacteria > Actinomycetota > Actinomycetes > Micrococcales > Microbacteriaceae > Agrococcus

Accessions

  • Primary accession
    U1MVJ6

Proteomes

Subcellular Location

Interaction

Subunit

Homodimer.

Family & Domains

Sequence similarities

Belongs to the HAM1 NTPase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    210
  • Mass (Da)
    21,939
  • Last updated
    2013-11-13 v1
  • Checksum
    9368516FDD272BFB
MSPVDTGFGSTGIDPRGGGLQVVVATRNPHKVEELQRILAPLLPGIELLPDDGPEPIEDGDTFEANALIKARAAHERTGLPAIADDSGIEVDALDGAPGIHSARYAGTRDDRDNLELLLANLAEHADRGARFVCAAAWVDAEGEFAVRGEWAGEVADAPRGDGGFGYDPIFVPHDGGGRSSAELSADEKDALSHRRIAFAALAECIRGGA

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
ASHR01000017
EMBL· GenBank· DDBJ
ERG64670.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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