U1MSJ2 · U1MSJ2_9MICO
- ProteinPhosphopantetheine adenylyltransferase
- GenecoaD
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids160 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.
Catalytic activity
- (R)-4'-phosphopantetheine + ATP + H+ = 3'-dephospho-CoA + diphosphate
Cofactor
Pathway
Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 4/5.
Features
Showing features for binding site, site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 10 | substrate | ||||
Sequence: S | ||||||
Binding site | 10-11 | ATP (UniProtKB | ChEBI) | ||||
Sequence: SF | ||||||
Binding site | 18 | ATP (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Site | 18 | Transition state stabilizer | ||||
Sequence: H | ||||||
Binding site | 42 | substrate | ||||
Sequence: K | ||||||
Binding site | 78 | substrate | ||||
Sequence: L | ||||||
Binding site | 92 | substrate | ||||
Sequence: K | ||||||
Binding site | 93-95 | ATP (UniProtKB | ChEBI) | ||||
Sequence: GIR | ||||||
Binding site | 103 | ATP (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 127-133 | ATP (UniProtKB | ChEBI) | ||||
Sequence: NAHVSSS |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | ATP binding | |
Molecular Function | pantetheine-phosphate adenylyltransferase activity | |
Biological Process | coenzyme A biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePhosphopantetheine adenylyltransferase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Actinomycetota > Actinomycetes > Micrococcales > Microbacteriaceae > Agrococcus
Accessions
- Primary accessionU1MSJ2
Proteomes
Subcellular Location
Interaction
Subunit
Homohexamer.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 7-137 | Cytidyltransferase-like | ||||
Sequence: VPGSFDPVTLGHLDVVARAARIFDEVHVVVTHNPDKHAFLPVVEREALIERSIEEARIEGQIRIANWSMGLLVDYCQQVGAEVLVKGIRSSTDLSYETPMSIVNRNLAGVETIFMLPNPENAHVSSSLVRQ |
Sequence similarities
Belongs to the bacterial CoaD family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length160
- Mass (Da)17,598
- Last updated2013-11-13 v1
- Checksum9B335BDC86F23162
Keywords
- Technical term