T5CHY8 · T5CHY8_HELPX

Function

function

NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site9-28NAD+ (UniProtKB | ChEBI)
Binding site53substrate
Binding site56substrate
Binding site86-89NAD+ (UniProtKB | ChEBI)
Active site104Proton acceptor
Binding site169-171NAD+ (UniProtKB | ChEBI)
Binding site209NAD+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionNAD+ binding
Molecular FunctionNAD-dependent histone deacetylase activity
Molecular Functionprotein-malonyllysine demalonylase activity
Molecular Functionprotein-succinyllysine desuccinylase activity
Molecular Functiontransferase activity
Biological Processprotein deacetylation

Keywords

  • Molecular function
  • Ligand
    • #NAD

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    NAD-dependent protein deacylase
  • EC number
  • Alternative names
    • Regulatory protein SIR2 homolog

Gene names

    • Name
      cobB
    • ORF names
      N411_07270

Organism names

  • Taxonomic identifier
  • Strain
    • FD535
  • Taxonomic lineage
    Bacteria > Campylobacterota > Epsilonproteobacteria > Campylobacterales > Helicobacteraceae > Helicobacter

Accessions

  • Primary accession
    T5CHY8

Proteomes

Subcellular Location

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-227Deacetylase sirtuin-type

Domain

2 residues (Tyr-53 and Arg-56) present in a large hydrophobic pocket are probably involved in substrate specificity. They are important for desuccinylation activity, but dispensable for deacetylation activity.

Sequence similarities

Belongs to the sirtuin family. Class III subfamily.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    229
  • Mass (Da)
    26,097
  • Last updated
    2013-11-13 v1
  • MD5 Checksum
    B5FF8800AFB84D3938BAB9069B25BB13
MKNLVILSGAGISAESGIKTFRDTDGLWEGHDIMEVASPYGWKKNPQKVLDFYNQRRRQLFEVYPNKAHEILVQLEKHYQVHIITQNVDDLHERAGSSRILHLHGELLSVRSEKDPNLVYRWEKDLNLGDLAKDKSQLRPDIVWFGEEVPLLKEAISLVKQAHLLIIIGTSLQVYPAASLYTHASKDALIYYIDPKAKNAHLPQNVQCINESAVHAMQDLMPKLIEMAS

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AKHP02000042
EMBL· GenBank· DDBJ
EQL56887.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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