T2GCZ8 · T2GCZ8_MEGG1

Function

function

Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site10ATP (UniProtKB | ChEBI)
Binding site58ATP (UniProtKB | ChEBI)
Binding site86ATP (UniProtKB | ChEBI)
Binding site92ATP (UniProtKB | ChEBI)
Binding site103ATP (UniProtKB | ChEBI)
Binding site113ATP (UniProtKB | ChEBI)
Active site116Pros-phosphohistidine intermediate

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionATP binding
Molecular Functionmetal ion binding
Molecular Functionnucleoside diphosphate kinase activity
Biological ProcessCTP biosynthetic process
Biological ProcessGTP biosynthetic process
Biological ProcessUTP biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Nucleoside diphosphate kinase
  • EC number
  • Short names
    NDK
    ; NDP kinase
  • Alternative names
    • Nucleoside-2-P kinase

Gene names

    • Name
      ndk
    • ORF names
      DGI_2724

Organism names

Accessions

  • Primary accession
    T2GCZ8

Proteomes

Subcellular Location

Keywords

PTM/Processing

Keywords

Interaction

Subunit

Homotetramer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain2-139Nucleoside diphosphate kinase-like

Sequence similarities

Belongs to the NDK family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    139
  • Mass (Da)
    14,930
  • Last updated
    2013-11-13 v1
  • Checksum
    B121781E8FEC66C7
MLQRTLSIIKPDAVSRNLAGDILAMIQAAGLTVKATKMIQLTRAQAEAFYAVHKERPFYGSLCDFMTSGPVVVSALEGENAIQAYRDLMGATNPANAAEGTIRKRFALDVEKNAVHGSDAPETAAQEIPFFFSALEIVG

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP006585
EMBL· GenBank· DDBJ
AGW14455.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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