T2G9E0 · T2G9E0_MEGG1

Function

function

Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.

Catalytic activity

Cofactor

adenosylcob(III)alamin (UniProtKB | Rhea| CHEBI:18408 )

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Molecular FunctionATP binding
Molecular Functioncobalamin binding
Molecular Functionribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
Biological Processdeoxyribonucleotide biosynthetic process
Biological ProcessDNA biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Vitamin B12-dependent ribonucleotide reductase
  • EC number

Gene names

    • ORF names
      DGI_0841

Organism names

Accessions

  • Primary accession
    T2G9E0

Proteomes

PTM/Processing

Keywords

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain20-100Ribonucleotide reductase large subunit N-terminal
Domain104-426Ribonucleotide reductase large subunit C-terminal
Domain431-579Ribonucleotide reductase large subunit C-terminal

Sequence similarities

Belongs to the ribonucleoside diphosphate reductase class-2 family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    757
  • Mass (Da)
    82,099
  • Last updated
    2013-11-13 v1
  • Checksum
    DAB1FBDAD6F87CDF
MTTPSAVLSAMPSSLPAPQLSPNAETVLAKRYLRKNLQGEITETPQELFWRVATAVAEAERAYPDSPWSAETLAEAFYLMMSRFDFLPNSPTLMNAGACLGQLAACFVLPVADSIDDIFDAVKHAALIHKSGGGTGFSFSRLRPKNSRVGSTGGVASGPLSFLRIFNTATEQIKQGGTRRGANMGILRVDHPDILEFIAAKEKEGELNNFNLSVALTEAFMQAVEKDAEYSLVEPHTGQEVQRLKAKDVFELLVTKAWASGDPGIIFLDRINRDNPTPDQGEIESTNPCGEQPLLPYEACNLGSLNLSQFHLPGDVSPSGVHGSIDWDRLKETVQLAVRFLDNVIDVSRYPLEQITDTVRRNRKIGLGVMGFADLLFQLRIPYNSAEALDLGERIMECIQDESKAASALLAAERGPFPAYATSAFAARKEGPYRNATTTTIAPTGTLSILAACSSGIEPLFALAFTRHVLDGAKLMESNPFFEDALRESGHHSPALMEDVATKGTVHHMRHLPDWIRRVFVTSHDISGEYHLKMQAAFQRFTDNAVSKTVNLPNAASKDDVRQIYTMAYTLGCKGVTVYRDGCKQVQVLCTGEQGQAQPADGKPSKVKQRPEVIYGFTHKINTGLGILYLTVNEIDGRPFEVFATIGKSGRSITAKAEAIGRLVSLALRSGVEPAAIVGQLKGIGGEHPVFRKKGMIQSIPDAVAWVFETHYMGGTDTSAPAEKNGLASPVCPDCGGDLIYQEGCFCCQGCAYTKCG

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP006585
EMBL· GenBank· DDBJ
AGW12736.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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