T2G6R0 · T2G6R0_MEGG1
- ProteinUDP-N-acetylmuramoylalanine--D-glutamate ligase
- GenemurD
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids432 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
Catalytic activity
- ATP + D-glutamate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine = ADP + H+ + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate
Pathway
Cell wall biogenesis; peptidoglycan biosynthesis.
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | ATP binding | |
Molecular Function | UDP-N-acetylmuramoylalanine-D-glutamate ligase activity | |
Biological Process | cell division | |
Biological Process | cell wall organization | |
Biological Process | peptidoglycan biosynthetic process | |
Biological Process | regulation of cell shape |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameUDP-N-acetylmuramoylalanine--D-glutamate ligase
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Thermodesulfobacteriota > Desulfovibrionia > Desulfovibrionales > Desulfovibrionaceae > Megalodesulfovibrio
Accessions
- Primary accessionT2G6R0
Proteomes
Subcellular Location
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 117-224 | Mur ligase central | ||||
Sequence: VTGTSGKTTTVTLAARMLEAAGKKVFLGGNIGTPLAEFVLSGETADVLVLEISSFQLQTCTTFHPRVGVFLNLAPNHLDYHADMEEYLQAKCMLFAQQTAADVAVVHA | ||||||
Domain | 292-403 | Mur ligase C-terminal | ||||
Sequence: HRIQPVAEVKGVLFVNDSKATTPDAMAAAIRSMDRPVRLLAGGVFKGGDLTELTPLIREKVRQVALFGANRDVFEQAWQGVAPLSWDDTLEQAARRLFAEAQPGEAILLSPA |
Sequence similarities
Belongs to the MurCDEF family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length432
- Mass (Da)46,080
- Last updated2013-11-13 v1
- ChecksumB965007D974F957F
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP006585 EMBL· GenBank· DDBJ | AGW12270.1 EMBL· GenBank· DDBJ | Genomic DNA |