T2A4B3 · T2A4B3_9LACO

Function

function

Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate.

Miscellaneous

There are 2 substrate-binding sites: the catalytic A site, and the non-catalytic B site that may play a role in the transfer of substrate or product between the active site and the solvent. Alternatively, the B site may bind allosteric effectors.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Pathway

Carbohydrate metabolism; tricarboxylic acid cycle; (S)-malate from fumarate: step 1/1.

Features

Showing features for binding site, active site, site.

TypeIDPosition(s)Description
Binding site100-102substrate
Binding site136-138substrate
Binding site183substrate
Active site184Proton donor/acceptor
Active site314
Binding site315substrate
Binding site320-322substrate
Site327Important for catalytic activity

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionfumarate hydratase activity
Biological Processfumarate metabolic process
Biological Processtricarboxylic acid cycle

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Fumarate hydratase class II
  • EC number
  • Short names
    Fumarase C
  • Alternative names
    • Aerobic fumarase
    • Iron-independent fumarase

Gene names

    • Name
      fumC

Organism names

  • Taxonomic identifier
  • Strain
    • PM1
  • Taxonomic lineage
    Bacteria > Bacillota > Bacilli > Lactobacillales > Lactobacillaceae > Limosilactobacillus

Accessions

  • Primary accession
    T2A4B3

Subcellular Location

Keywords

Interaction

Subunit

Homotetramer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain12-338Fumarate lyase N-terminal
Domain405-457Fumarase C C-terminal

Sequence similarities

Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    462
  • Mass (Da)
    50,121
  • Last updated
    2013-11-13 v1
  • Checksum
    B00732221F6B6F7A
MSDYRTEEDTLGPVKIPADALWGPQTERSRNNFPTGQYMPLAIIHALLNIKKAAAQANMETKAISDEKGNLIVKAIDELLALSDEDLRKDFPLKVYQTGSGTQTNMNTNEVVAHKAHQLNPDIEILPNDDVNKGQSSNDTFPTAMNVVALEALDKLKPAVQHLIDELKVKQDKYWKTVKVGRTHLQDAVPLTFGQEVSGYVAALEHDLDYIKTLEPTLNELAIGGTAVGTGLNAAEGMPEKIAEKLSAVYGLNLTAKSNKFYGLANHSGLDVVHGALKTLAADMFKIAQDIRFLASGPRAGYDELNIPANEPGSSIMPGKVNPTQAEAVTMAALRVFGNDTVVTMASSQGNFEMNVYKPVMIDAFLESADLLAGTITGFTDRCVKGLTVNEKRMAELVDNSLMTVTALSPHIGYHDSAKIAQAADKAGSTLKEAALKSGKVTEEQYDEWMDMLKMTNADRKD

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KF312445
EMBL· GenBank· DDBJ
AGU90233.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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