T1Q061 · T1Q061_POLSP
- ProteinHypoxia-inducible factor 1-alpha
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids784 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score2/5
Function
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | nucleus | |
Molecular Function | DNA-binding transcription factor activity, RNA polymerase II-specific | |
Molecular Function | protein dimerization activity | |
Molecular Function | RNA polymerase II transcription regulatory region sequence-specific DNA binding | |
Biological Process | cellular response to hypoxia |
Keywords
- Molecular function
- Biological process
Names & Taxonomy
Protein names
- Recommended nameHypoxia-inducible factor 1-alpha
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Chondrostei > Acipenseriformes > Polyodontidae > Polyodon
Accessions
- Primary accessionT1Q061
PTM/Processing
Features
Showing features for modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Modified residue | 404 | 4-hydroxyproline | ||||
Sequence: P | ||||||
Modified residue | 557 | 4-hydroxyproline | ||||
Sequence: P | ||||||
Modified residue | 761 | (3S)-3-hydroxyasparagine | ||||
Sequence: N |
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for region, domain, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-25 | Disordered | ||||
Sequence: MEVVEVTEKKRVSSDRRKEKSRDAA | ||||||
Domain | 16-69 | BHLH | ||||
Sequence: RRKEKSRDAARCRRGKESEVFYELAHELPLPHNVTSHLDKASIMRLILSYLRMR | ||||||
Domain | 80-148 | PAS | ||||
Sequence: EESELESQFNNFYLKALDGFVMVLSEDGDMVYLSENVSKCMGLTQFELTGHSLFDFAHPCDHEELREVL | ||||||
Domain | 248-299 | PAS | ||||
Sequence: SLDMKFSYCDERITELMGYQPEDLLGRSVYEYYHALDSDHLTKTHHDLFAKG | ||||||
Region | 486-509 | Disordered | ||||
Sequence: TIPQTPDLSLPSTTQSSPEPSSPS | ||||||
Region | 623-642 | Disordered | ||||
Sequence: SAPNSPFSGKNSRTESPIRK | ||||||
Compositional bias | 626-641 | Polar residues | ||||
Sequence: NSPFSGKNSRTESPIR | ||||||
Region | 650-683 | Disordered | ||||
Sequence: LEEQSNQSHPVTPLISKRPTAFSEELSPKTLAQR |
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length784
- Mass (Da)87,777
- Last updated2013-11-13 v1
- Checksum57F42A72EE8AC1B8
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 626-641 | Polar residues | ||||
Sequence: NSPFSGKNSRTESPIR |