T1G815 · T1G815_HELRO

Function

function

Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.

Activity regulation

Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.

Pathway

Carbohydrate metabolism; D-ribose degradation; D-ribose 5-phosphate from beta-D-ribopyranose: step 2/2.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site12-14substrate
Binding site40-44substrate
Binding site141substrate
Binding site186ATP (UniProtKB | ChEBI)
Binding site223-228ATP (UniProtKB | ChEBI)
Binding site251K+ (UniProtKB | ChEBI)
Binding site253K+ (UniProtKB | ChEBI)
Binding site256-257ATP (UniProtKB | ChEBI)
Active site257Proton acceptor
Binding site257substrate
Binding site292K+ (UniProtKB | ChEBI)
Binding site295K+ (UniProtKB | ChEBI)
Binding site297K+ (UniProtKB | ChEBI)
Binding site301K+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Cellular Componentnucleus
Molecular FunctionATP binding
Molecular Functionmetal ion binding
Molecular Functionribokinase activity
Biological ProcessD-ribose catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Ribokinase
  • EC number
  • Short names
    RK

Gene names

    • Name
      20217212
    • ORF names
      HELRODRAFT_91240

Organism names

Accessions

  • Primary accession
    T1G815

Proteomes

Subcellular Location

Cytoplasm
Nucleus

Keywords

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain4-303Carbohydrate kinase PfkB

Sequence similarities

Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    319
  • Mass (Da)
    34,039
  • Last updated
    2013-10-16 v1
  • Checksum
    AD83588A4CA04BF1
MAVDVVVVGSCMTDLISYVPRLPKPGETLHGNAFKMGFGGKGANQCVAAAKLGASVAMVGKVGDDVFGHNYMKNFEQHQVNCDNMHMSSTSSTGMASISVAEDGANSIVIVAGANLELTEDDIMKAEPIISNCKVLICQLEINQQVTLAALKLAKKHGVFTILNPAPAPSTFNTELLKYTDIVCPNETESEIITSHPITNIDDAIESLHHFFELGCLGTVIITLGAKGCVFRCKSEENHLHVGCTQVSATDTTGAGDAFVGTLAYCLTRGIPLTVEHLSILVRISCDVATVSVQKKGTQDSYPCFDELSLDIQENFKLL

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AMQM01008537
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
KB097792
EMBL· GenBank· DDBJ
ESN89903.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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