T1CNC9 · T1CNC9_9PORP

Function

function

Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Features

Showing features for active site.

TypeIDPosition(s)Description
Active site49
Active site330Nucleophile

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionL-methionine:thioredoxin-disulfide S-oxidoreductase activity
Molecular Functionpeptide-methionine (R)-S-oxide reductase activity
Molecular Functionpeptide-methionine (S)-S-oxide reductase activity
Biological Processprotein modification process
Biological Processprotein repair
Biological Processresponse to oxidative stress

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Multifunctional fusion protein

Including 2 domains:

  • Recommended name
    Peptide methionine sulfoxide reductase MsrA
  • EC number
  • Short names
    Protein-methionine-S-oxide reductase
  • Alternative names
    • Peptide-methionine (S)-S-oxide reductase
      (Peptide Met(O) reductase
      )
  • Recommended name
    Peptide methionine sulfoxide reductase MsrB
  • EC number
  • Alternative names
    • Peptide-methionine (R)-S-oxide reductase

Gene names

    • Name
      msrA
    • Synonyms
      msrB
    • ORF names
      PORCRE_1007

Organism names

Accessions

  • Primary accession
    T1CNC9

Proteomes

Subcellular Location

PTM/Processing

Features

Showing features for signal, chain.

TypeIDPosition(s)Description
Signal1-19
ChainPRO_500457421720-367Multifunctional fusion protein

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain218-341MsrB

Sequence similarities

Belongs to the MsrA Met sulfoxide reductase family.
Belongs to the MsrB Met sulfoxide reductase family.
In the C-terminal section; belongs to the MsrB Met sulfoxide reductase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    367
  • Mass (Da)
    41,824
  • Last updated
    2013-10-16 v1
  • Checksum
    762DED21FA541C76
MKKASILIFSIAALSLVFARTQVVQTKENRKEKMEDVKMKKEIYLAGGCFWGTEHFLKQIRGVIKTEVGYANGKGEHPDYKSVSTGEPGFAETVKVEYAPDQISLEKLLDLFFETIDPTAVNKQGNDVGVQYRTGIYYTDMADAPMVRASIDKLAAMHSQPIAIESKALENYYTAEEYHQDYLDKHPNGYCHIPKSLFQMAREANPAFSEEKYIRMTDEDLKEKLTPLQYDVTRNNATEAPFRNEYWDEFGEGIYVDITTGEPLFVSTDKFESGCGWPSFSKPIDKTLVMEKTDKSYGMVRTEIRSKTGDAHLGHVFNDGPAEKGGLRYCINSAALRFIPKEKMKEEGYEDYIFLLKKELPFKTKQI

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BAOU01000024
EMBL· GenBank· DDBJ
GAD05307.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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