T0RMM8 · T0RMM8_SAPDV
- ProteinLysosomal dipeptide transporter MFSD1
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids531 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Lysosomal dipeptide uniporter that selectively exports lysine, arginine or histidine-containing dipeptides with a net positive charge from the lysosome lumen into the cytosol. Could play a role in a specific type of protein O-glycosylation indirectly regulating macrophages migration and tissue invasion. Also essential for liver homeostasis.
Catalytic activity
- L-alanyl-L-lysine(out) = L-alanyl-L-lysine(in)
- L-alpha-aminoacyl-L-arginine(out) = L-alpha-aminoacyl-L-arginine(in)
- L-alpha-aminoacyl-L-histidine(out) = L-alpha-aminoacyl-L-histidine(in)
- L-alpha-aminoacyl-L-lysine(out) = L-alpha-aminoacyl-L-lysine(in)
- L-arginyl-L-alpha-amino acid(out) = L-arginyl-L-alpha-amino acid(in)
- L-arginyl-glycine(out) = L-arginyl-glycine(in)
- L-aspartyl-L-lysine(out) = L-aspartyl-L-lysine(in)
- L-histidyl-L-alpha-amino acid(out) = L-histidyl-L-alpha-amino acid(in)
- L-histidyl-glycine(out) = L-histidyl-glycine(in)
- L-lysyl-L-alanine(out) = L-lysyl-L-alanine(in)
- L-lysyl-L-alpha-amino acid(out) = L-lysyl-L-alpha-amino acid(in)
- L-lysyl-L-lysine(out) = L-lysyl-L-lysine(in)
- L-lysyl-glycine(out) = L-lysyl-glycine(in)
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | lysosomal membrane | |
Molecular Function | transmembrane transporter activity |
Keywords
- Biological process
Names & Taxonomy
Protein names
- Recommended nameLysosomal dipeptide transporter MFSD1
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Sar > Stramenopiles > Oomycota > Saprolegniales > Saprolegniaceae > Saprolegnia
Accessions
- Primary accessionT0RMM8
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Lysosome membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 49-70 | Helical | ||||
Sequence: EMAFNLLYTVYSVPNIVLPLFG | ||||||
Transmembrane | 82-100 | Helical | ||||
Sequence: MLLLVTLLILIGHGIFAVG | ||||||
Transmembrane | 174-195 | Helical | ||||
Sequence: AIWAGVVVCALAFLATLALYRI | ||||||
Transmembrane | 215-235 | Helical | ||||
Sequence: IIDFSTSFWLMAGAFFVLYAV | ||||||
Transmembrane | 345-366 | Helical | ||||
Sequence: AFPLSIAPLLVATTAPLSGYLV | ||||||
Transmembrane | 373-395 | Helical | ||||
Sequence: AALATGAMVLLGLSHALIGYTWL | ||||||
Transmembrane | 401-424 | Helical | ||||
Sequence: LVLQGIGFSVFLSALWPAVSYCVA | ||||||
Transmembrane | 431-451 | Helical | ||||
Sequence: AYGVLCAVLNFGLALVPMLVV | ||||||
Transmembrane | 463-485 | Helical | ||||
Sequence: YVNGMFIGLSLLGVGACAALCVV |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-25 | |||||
Sequence: MDDAQRRKPWVLLLACLVDIGNSYC | ||||||
Chain | PRO_5004584083 | 26-531 | Lysosomal dipeptide transporter MFSD1 | |||
Sequence: YDTPSALKSQLQEHLHGMPTASFEMAFNLLYTVYSVPNIVLPLFGGLVTDRIGPRSMLLLVTLLILIGHGIFAVGNQLQNVPVMLLGRVVFGLGGETISVAQATVLAVWFDSNELALANGFALSTSKLATTLNNELSPVLAEAFGLSSAIWAGVVVCALAFLATLALYRISERDAVDQDDDNVPVQLSDIIDFSTSFWLMAGAFFVLYAVTGPFNNVASSIFLERDYYKALPSACHRCGLGAYAGDVNCSMLPPACPPSPPYAYPLPLLSAHCTLNQTQCLRAPPYVLAHHINCDDTFWKNGEVTKGYCSVKYAAEQAAAFPLSIAPLLVATTAPLSGYLVDHLGHRAALATGAMVLLGLSHALIGYTWLSLYVPLVLQGIGFSVFLSALWPAVSYCVAPHHVGTAYGVLCAVLNFGLALVPMLVVVEHNLTGVYVPYVNGMFIGLSLLGVGACAALCVVDHANGGALDGVTMTQVQPTPVPLSELLTNEETSLVQAPTVGYGTYS |
Interaction
Subunit
Homodimer. Interacts with lysosomal protein GLMP (via lumenal domain); the interaction starts while both proteins are still in the endoplasmic reticulum and is required for stabilization of MFSD1 in lysosomes but has no direct effect on its targeting to lysosomes or transporter activity.
Protein-protein interaction databases
Structure
Sequence
- Sequence statusComplete
- Length531
- Mass (Da)56,494
- Last updated2013-10-16 v1
- Checksum1C21FBF6D0D82AB3
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
JH767170 EMBL· GenBank· DDBJ | EQC31217.1 EMBL· GenBank· DDBJ | Genomic DNA |