T0RMM8 · T0RMM8_SAPDV

Function

function

Lysosomal dipeptide uniporter that selectively exports lysine, arginine or histidine-containing dipeptides with a net positive charge from the lysosome lumen into the cytosol. Could play a role in a specific type of protein O-glycosylation indirectly regulating macrophages migration and tissue invasion. Also essential for liver homeostasis.

Catalytic activity

  • L-alanyl-L-lysine(out) = L-alanyl-L-lysine(in)
  • L-alpha-aminoacyl-L-arginine(out) = L-alpha-aminoacyl-L-arginine(in)
  • L-alpha-aminoacyl-L-histidine(out) = L-alpha-aminoacyl-L-histidine(in)
  • L-alpha-aminoacyl-L-lysine(out) = L-alpha-aminoacyl-L-lysine(in)
  • L-arginyl-L-alpha-amino acid(out) = L-arginyl-L-alpha-amino acid(in)
  • L-arginyl-glycine(out) = L-arginyl-glycine(in)
  • L-aspartyl-L-lysine(out) = L-aspartyl-L-lysine(in)
  • L-histidyl-L-alpha-amino acid(out) = L-histidyl-L-alpha-amino acid(in)
  • L-histidyl-glycine(out) = L-histidyl-glycine(in)
  • L-lysyl-L-alanine(out) = L-lysyl-L-alanine(in)
  • L-lysyl-L-alpha-amino acid(out) = L-lysyl-L-alpha-amino acid(in)
  • L-lysyl-L-lysine(out) = L-lysyl-L-lysine(in)
  • L-lysyl-glycine(out) = L-lysyl-glycine(in)

GO annotations

AspectTerm
Cellular Componentlysosomal membrane
Molecular Functiontransmembrane transporter activity

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Lysosomal dipeptide transporter MFSD1
  • Alternative names
    • Major facilitator superfamily domain-containing protein 1

Gene names

    • ORF names
      SDRG_11140

Organism names

Accessions

  • Primary accession
    T0RMM8

Proteomes

Organism-specific databases

Subcellular Location

Lysosome membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane49-70Helical
Transmembrane82-100Helical
Transmembrane174-195Helical
Transmembrane215-235Helical
Transmembrane345-366Helical
Transmembrane373-395Helical
Transmembrane401-424Helical
Transmembrane431-451Helical
Transmembrane463-485Helical

Keywords

PTM/Processing

Features

Showing features for signal, chain.

TypeIDPosition(s)Description
Signal1-25
ChainPRO_500458408326-531Lysosomal dipeptide transporter MFSD1

Interaction

Subunit

Homodimer. Interacts with lysosomal protein GLMP (via lumenal domain); the interaction starts while both proteins are still in the endoplasmic reticulum and is required for stabilization of MFSD1 in lysosomes but has no direct effect on its targeting to lysosomes or transporter activity.

Protein-protein interaction databases

Family & Domains

Sequence similarities

Belongs to the major facilitator superfamily.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    531
  • Mass (Da)
    56,494
  • Last updated
    2013-10-16 v1
  • Checksum
    1C21FBF6D0D82AB3
MDDAQRRKPWVLLLACLVDIGNSYCYDTPSALKSQLQEHLHGMPTASFEMAFNLLYTVYSVPNIVLPLFGGLVTDRIGPRSMLLLVTLLILIGHGIFAVGNQLQNVPVMLLGRVVFGLGGETISVAQATVLAVWFDSNELALANGFALSTSKLATTLNNELSPVLAEAFGLSSAIWAGVVVCALAFLATLALYRISERDAVDQDDDNVPVQLSDIIDFSTSFWLMAGAFFVLYAVTGPFNNVASSIFLERDYYKALPSACHRCGLGAYAGDVNCSMLPPACPPSPPYAYPLPLLSAHCTLNQTQCLRAPPYVLAHHINCDDTFWKNGEVTKGYCSVKYAAEQAAAFPLSIAPLLVATTAPLSGYLVDHLGHRAALATGAMVLLGLSHALIGYTWLSLYVPLVLQGIGFSVFLSALWPAVSYCVAPHHVGTAYGVLCAVLNFGLALVPMLVVVEHNLTGVYVPYVNGMFIGLSLLGVGACAALCVVDHANGGALDGVTMTQVQPTPVPLSELLTNEETSLVQAPTVGYGTYS

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JH767170
EMBL· GenBank· DDBJ
EQC31217.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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