T0RG20 · T0RG20_SAPDV

Function

function

Lysosomal dipeptide uniporter that selectively exports lysine, arginine or histidine-containing dipeptides with a net positive charge from the lysosome lumen into the cytosol. Could play a role in a specific type of protein O-glycosylation indirectly regulating macrophages migration and tissue invasion. Also essential for liver homeostasis.

Catalytic activity

  • L-alanyl-L-lysine(out) = L-alanyl-L-lysine(in)
  • L-alpha-aminoacyl-L-arginine(out) = L-alpha-aminoacyl-L-arginine(in)
  • L-alpha-aminoacyl-L-histidine(out) = L-alpha-aminoacyl-L-histidine(in)
  • L-alpha-aminoacyl-L-lysine(out) = L-alpha-aminoacyl-L-lysine(in)
  • L-arginyl-L-alpha-amino acid(out) = L-arginyl-L-alpha-amino acid(in)
  • L-arginyl-glycine(out) = L-arginyl-glycine(in)
  • L-aspartyl-L-lysine(out) = L-aspartyl-L-lysine(in)
  • L-histidyl-L-alpha-amino acid(out) = L-histidyl-L-alpha-amino acid(in)
  • L-histidyl-glycine(out) = L-histidyl-glycine(in)
  • L-lysyl-L-alanine(out) = L-lysyl-L-alanine(in)
  • L-lysyl-L-alpha-amino acid(out) = L-lysyl-L-alpha-amino acid(in)
  • L-lysyl-L-lysine(out) = L-lysyl-L-lysine(in)
  • L-lysyl-glycine(out) = L-lysyl-glycine(in)

GO annotations

AspectTerm
Cellular Componentlysosomal membrane
Molecular Functiontransmembrane transporter activity

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Lysosomal dipeptide transporter MFSD1
  • Alternative names
    • Major facilitator superfamily domain-containing protein 1

Gene names

    • ORF names
      SDRG_11151

Organism names

Accessions

  • Primary accession
    T0RG20

Proteomes

Organism-specific databases

Subcellular Location

Lysosome membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane57-75Helical
Transmembrane82-101Helical
Transmembrane107-127Helical
Transmembrane165-194Helical
Transmembrane221-241Helical
Transmembrane373-394Helical
Transmembrane401-423Helical
Transmembrane435-455Helical
Transmembrane467-489Helical

Keywords

PTM/Processing

Features

Showing features for signal, chain.

TypeIDPosition(s)Description
Signal1-25
ChainPRO_500458395226-521Lysosomal dipeptide transporter MFSD1

Interaction

Subunit

Homodimer. Interacts with lysosomal protein GLMP (via lumenal domain); the interaction starts while both proteins are still in the endoplasmic reticulum and is required for stabilization of MFSD1 in lysosomes but has no direct effect on its targeting to lysosomes or transporter activity.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-494Major facilitator superfamily (MFS) profile

Sequence similarities

Belongs to the major facilitator superfamily.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    521
  • Mass (Da)
    56,006
  • Last updated
    2013-10-16 v1
  • Checksum
    7F3DB9B0C88D5612
MRGSAWQRRSVLALSSLFVLGSTYCYDNPGALKTQLQQHFGRTIPRAEFEVYFNLSYSLYSVPNVLLPFFGGVLIDTYGVSFMALVLASLILAGQVVTALGSSFENIYLLLAGRVLFGLGGETMWVAQTTFVTHWFSPMELGFAIGINNCVATLGTLLNDVLSPWIAAAFDVTFALWVGSFVCVFSLCATILLVRLESTLPFERASPAAPVRLWDLRRFSLGFWLIAVLYIVINACTGPFANVAGSVLLERNYFIEPPIDCRRCGLGAYLNHTCETLAPSCPMSPPFAWPLPQLAANCSIVSAFDQFKCKKGPPYLQDDQINCDATAWRHGPLTHIYCSKKIDATAKATAMMAITPLVSAVFSPLSGSLVDGLGARASLGLVADVAIAAGHVLVRYTTSDVALALTLSGIGQSLFAAAMWSAIPFVVPPRYVSTAFGAITSLSNVGLATVPLIVAHVYSRQQHYLPSVANVFVVLSACGVVLGLCLLVADATVLRRALSRREVAEASASTEQLLDASDRDL

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JH767170
EMBL· GenBank· DDBJ
EQC31228.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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