S9UPX9 · S9UPX9_9TRYP
- ProteinHistone-lysine N-methyltransferase, H3 lysine-79 specific
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids292 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Histone methyltransferase that specifically trimethylates histone H3 to form H3K79me3. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histone.
Miscellaneous
In contrast to other lysine histone methyltransferases, it does not contain a SET domain, suggesting the existence of another mechanism for methylation of lysine residues of histones.
Catalytic activity
- L-lysyl79-[histone H3] + 3 S-adenosyl-L-methionine = N6,N6,N6-trimethyl-L-lysyl79-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H+
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | nucleus | |
Molecular Function | histone H3K79 trimethyltransferase activity | |
Biological Process | DNA damage checkpoint signaling | |
Biological Process | DNA repair | |
Biological Process | methylation |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameHistone-lysine N-methyltransferase, H3 lysine-79 specific
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Discoba > Euglenozoa > Kinetoplastea > Metakinetoplastina > Trypanosomatida > Trypanosomatidae > Strigomonadinae > Strigomonas
Accessions
- Primary accessionS9UPX9
Proteomes
Subcellular Location
Structure
Family & Domains
Sequence
- Sequence statusComplete
- Length292
- Mass (Da)32,806
- Last updated2013-10-16 v1
- ChecksumE4E52D17F9500451
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
ATMH01007419 EMBL· GenBank· DDBJ | EPY23856.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
ATMH01003859 EMBL· GenBank· DDBJ | EPY30844.1 EMBL· GenBank· DDBJ | Genomic DNA |