S9UPX9 · S9UPX9_9TRYP

  • Protein
    Histone-lysine N-methyltransferase, H3 lysine-79 specific
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    2/5

Function

function

Histone methyltransferase that specifically trimethylates histone H3 to form H3K79me3. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histone.

Miscellaneous

In contrast to other lysine histone methyltransferases, it does not contain a SET domain, suggesting the existence of another mechanism for methylation of lysine residues of histones.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

GO annotations

AspectTerm
Cellular Componentnucleus
Molecular Functionhistone H3K79 trimethyltransferase activity
Biological ProcessDNA damage checkpoint signaling
Biological ProcessDNA repair
Biological Processmethylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Histone-lysine N-methyltransferase, H3 lysine-79 specific
  • EC number
  • Alternative names
    • Histone H3-K79 methyltransferase

Gene names

    • ORF names
      STCU_03859
      , STCU_07419

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Discoba > Euglenozoa > Kinetoplastea > Metakinetoplastina > Trypanosomatida > Trypanosomatidae > Strigomonadinae > Strigomonas

Accessions

  • Primary accession
    S9UPX9

Proteomes

Subcellular Location

Keywords

  • Cellular component

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-292DOT1

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    292
  • Mass (Da)
    32,806
  • Last updated
    2013-10-16 v1
  • Checksum
    E4E52D17F9500451
MKAKRTRTASISHGKQISQFLSSNAAQPCKVFKTDAATIHQVEEGDGSPQHPFRLPLRTVPNNSGCYHCQDDKCSCVFFTDLLDETYKNIAKKRVVEVTRSRSLCAKSLLPTFVSRIIKIMNITKDDTFYDFGCGNGSILFQIAHSTGASCIGIEISEQNADVAREAHAYLTAKLKDQSASHFPSIKIVTDDITKYLAAEPLKEHAKGKNLILLSNLLFPKPLTQFIAENLRKAPLGTQILCFDDLYPHGRTLAKIRDPEAFELFEMRDYVWQKESVEWCGAEGPFYVHTRK

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
ATMH01007419
EMBL· GenBank· DDBJ
EPY23856.1
EMBL· GenBank· DDBJ
Genomic DNA
ATMH01003859
EMBL· GenBank· DDBJ
EPY30844.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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