S9U7J3 · S9U7J3_9TRYP
- ProteinSuccinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids299 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
Catalytic activity
- succinate + ATP + CoA = succinyl-CoA + ADP + phosphate
Pathway
Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 23-26 | CoA (UniProtKB | ChEBI) | |||
Binding site | 49 | CoA (UniProtKB | ChEBI) | |||
Binding site | 102-104 | CoA (UniProtKB | ChEBI) | |||
Binding site | 166 | substrate; ligand shared with subunit beta | |||
Active site | 255 | Tele-phosphohistidine intermediate | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrion | |
Cellular Component | succinate-CoA ligase complex (ADP-forming) | |
Molecular Function | nucleotide binding | |
Molecular Function | succinate-CoA ligase (ADP-forming) activity | |
Molecular Function | succinate-CoA ligase (GDP-forming) activity | |
Biological Process | tricarboxylic acid cycle |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameSuccinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Discoba > Euglenozoa > Kinetoplastea > Metakinetoplastina > Trypanosomatida > Trypanosomatidae > Strigomonadinae > Strigomonas
Accessions
- Primary accessionS9U7J3
Proteomes
Subcellular Location
Interaction
Subunit
Heterodimer of an alpha and a beta subunit.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 10-106 | CoA-binding | |||
Sequence similarities
Belongs to the succinate/malate CoA ligase alpha subunit family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length299
- Mass (Da)30,875
- Last updated2013-10-16 v1
- Checksum3AEF7AB9E412C263
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
ATMH01006120 EMBL· GenBank· DDBJ | EPY26707.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
ATMH01003263 EMBL· GenBank· DDBJ | EPY31762.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
ATMH01000122 EMBL· GenBank· DDBJ | EPY37175.1 EMBL· GenBank· DDBJ | Genomic DNA |