S7ZZD2 · S7ZZD2_DACHA

Function

function

Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.
Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

biotin (UniProtKB | Rhea| CHEBI:57586 )

Pathway

Carbohydrate biosynthesis; gluconeogenesis.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site154ATP (UniProtKB | ChEBI)
Binding site238ATP (UniProtKB | ChEBI)
Binding site273ATP (UniProtKB | ChEBI)
Active site330
Binding site584Mn2+ (UniProtKB | ChEBI)
Binding site656substrate
Binding site752Mn2+ (UniProtKB | ChEBI); via carbamate group
Binding site782Mn2+ (UniProtKB | ChEBI)
Binding site784Mn2+ (UniProtKB | ChEBI)
Binding site917substrate

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionATP binding
Molecular Functionmetal ion binding
Molecular Functionpyruvate carboxylase activity
Biological Processgluconeogenesis
Biological Processpyruvate metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Pyruvate carboxylase
  • EC number

Gene names

    • ORF names
      H072_10766

Organism names

Accessions

  • Primary accession
    S7ZZD2

Proteomes

Subcellular Location

PTM/Processing

Features

Showing features for modified residue.

TypeIDPosition(s)Description
Modified residue752N6-carboxylysine
Modified residue1153N6-biotinyllysine

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain36-488Biotin carboxylation
Domain158-355ATP-grasp
Domain575-843Pyruvate carboxyltransferase
Domain1112-1187Lipoyl-binding

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,195
  • Mass (Da)
    131,429
  • Last updated
    2013-10-16 v1
  • Checksum
    98A4A964F386F564
MASKPYADVFEDDDVDGGSSTARSVHRIRSNSTIMQLKKIMVANRGEIPIRIFRTAHELSLQTVAIYSYEDRMGMHRQKADEAYMIGHRGQYTPVGAYLAIDEIIKIALEHNVNMIHPGYGFLSENAEFARKVEAAGIIFVGPTYKVIEALGDKVSARKIALQCNVPCVPGTPGPVESFDDCSTFVKEYGYPIIIKAAFGGGGRGMRVVREGDNLQDAFERATSEAKSAFGNGTVFIERFLDKPKHIEVQLLGDNQGNVVHLYERDCSVQRRHQKVVEIAPAKDLPPETRQAILDDAVRIAKSVNYRNAGTAEFLVDNQNRHYFIEINPRIQVEHTITEEITGIDIVAAQIQIAAGATLAQLGLTQDRISTRGFAIQCRVTTEDPSENFRPDTGKIEVYRSAGGNGVRLDGGNGFAGSIITPHYDSMLVKCTCHGSTYEIARRKVIRALVEFRIRGVKTNIPFLLSLLTHEVFINGTCWTTFIDDTPELFSLMKSQNRAQKLLAYLGDLSVNGSSIKGQVGQPKFKGEIIMPILHDSKTGQVIDTTQPCQKGWRNILMEQGPEAFAKAVRANKGCLLMDTTWRDAHQSLLATRVRTIDICEIAKHTSYAYSNAYSIECWGGATFDVAMRFLYEDPWDRLRKMRRLVPNVPFQMLLRGANGVAYSSLPDNAIEHFCEQARKNGVDIFRVFDALNDVDQLEVGIKAVKKAGGVVEAAICYSGDMLNPTKKYNLEYYLELAEKVVKLGTHILGIKDMAGCLRPRAATLLIGALREKYPDLPIHVHTHDSAGTGVASMAACAAAGADAVDTATDSLSGMTSQPSVGAVLAALEGTDMDPGLDINQVREIDSYWAQLRLMYSCFEAGLTGPDPEVYVHEIPGGQLTNLIFQASQLGLGAQWKETKKAYTQANYLLGDIVKVTPTSKVVGDLAQFMVSNKLTPEDVVERAETLDFPGSVIDFLEGLMGQPYGGFPEPLRSRALRGRRALNERPGLSLHPTDLQGIKQEILEKFGQASECDVASYVMYPKVFLDYKEFLAKYGDLSVLPTKYFLSTPEIGEEFHVQIEKGKTLIIKLLAVGPLSEQTGQREVFFELNGEVRQVTVDDKKAAVENTSRLKANQADSSQVGAPMSGVVVEVRVKDGSEVKKGDPIAVLSAMKMEMVISAPHSGVIAELQIKANDSVDGQDLICKIVKATEEKTE

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AQGS01001030
EMBL· GenBank· DDBJ
EPS35794.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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