S7J231 · S7J231_9FIRM

Function

function

Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

biotin (UniProtKB | Rhea| CHEBI:57586 )

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site119ATP (UniProtKB | ChEBI)
Binding site203ATP (UniProtKB | ChEBI)
Binding site238ATP (UniProtKB | ChEBI)
Active site295
Binding site541Mn2+ (UniProtKB | ChEBI)
Binding site613substrate
Binding site710Mn2+ (UniProtKB | ChEBI); via carbamate group
Binding site739Mn2+ (UniProtKB | ChEBI)
Binding site741Mn2+ (UniProtKB | ChEBI)
Binding site874substrate

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionATP binding
Molecular Functionmetal ion binding
Molecular Functionpyruvate carboxylase activity
Biological Processgluconeogenesis
Biological Processpyruvate metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Pyruvate carboxylase
  • EC number

Gene names

    • ORF names
      NM10_06128

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • NM10
  • Taxonomic lineage
    Bacteria > Bacillota > Negativicutes > Veillonellales > Veillonellaceae > Megasphaera

Accessions

  • Primary accession
    S7J231

Proteomes

Subcellular Location

PTM/Processing

Features

Showing features for modified residue.

TypeIDPosition(s)Description
Modified residue710N6-carboxylysine
Modified residue1109N6-biotinyllysine

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain3-456Biotin carboxylation
Domain123-320ATP-grasp
Domain532-800Pyruvate carboxyltransferase
Domain1074-1144Lipoyl-binding

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,144
  • Mass (Da)
    127,790
  • Last updated
    2013-10-16 v1
  • Checksum
    C88FC30FC52EFB8D
MKKIRSVLVANRGEIAIRVFRACNELGIRTVAIYSKEDSLSLHRFRADESYLVGEGKKPVDAYLDIEDIIRIAHEHDVDAIHPGYGFLSENADLAKRCEEEGIIFIGPKVEHLIMFGDKINARIQAKKAGIQYIPGSDGPVMNYAEVEKFAKQVGFPIMLKAVNGGGGRGMRMVDRMADLRDAYDRAKSEAKLAFGNDEIYLEKCIVNPKHVEVQIMGDEHGNVIHLFERDCSIQRRHQKVVETAPASALPVELRQKICNAALKLMKNVHYVNAGTVEFLVTPDGEFYFIEVNPRVQVEHTVTEMITGIDIVQTQIKVAEGYALDSDEIGIKSQDDVRCLGDAIQCRITTEDPMNNFMPDSGKIMVYRSGGGFGVRLDSGNAYTGAIITPYYDSLLVKTTTYGRTHKEAAEKMLRVLKEFRIRGVKTNIGFLINVLKSPEFIAGTYNVNFIDDHPELFNLPVVQDRGTKLLKYIGNTTINGYADAGHQDKPEFEALELPTPVAGPYPDGTKQKFDAMGPEKFSQWIKDQKKVFFTDTTMRDAHQSLFATRVRSIDMLRVLEAASKKLPNLFSYECWGGATFDVAYRFLYEDPWVRLHQMRKKAPNILLQMLVRGANAVGYTSYPDNVVKNFIDLSAKNGIDVFRVFDSLNSLDNMYGTIQAVRENNKLAEVALCYTGDILDPARDKYDLKYYVNMAKELQNAGANIIAIKDMAGLLKPEAAYRLVSALKDAVDLPIHLHTHDGSGNAICTYDRAIDAGVDIVDVAYSAFAGGTSQPSMSTLYYALSGKDRQPDLDVDAMEEMSRYWATVRPYYKGVDKADAYPNTEVYQHEMPGGQFSNLRQQAKAVGLGDRWNEIKKMYHTVSMMFGDIIKVTPSSKVVGDMTLFMVQNNLTEQDVYDKGDVLDFPQSVVEFFEGRIGIPYQGFPEKLQKIVLKGKKPLTERPGKSLAPVDFEAIRKKLTDAGYKHEDEDINAYCQYPKVFKDFNETVKKYGDVSVLDTPTFFFGMKKNEEVHVEIEEGKDLIITLINISDPDDSGVRTITFMFNGAEREIQVQDKSVDMKTVTRRKADPDKAGDIGATLSGSVVKVLVTKGQKVKKGEPLVVTEAMKMETTITSPIDGTVGEIYATKGQAIISGDCLLEVLA

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
APHY01000027
EMBL· GenBank· DDBJ
EPP18001.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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