S6BD07 · S6BD07_9GAMM

Function

function

DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Function3'-5' exonuclease activity
Molecular FunctionDNA binding
Molecular FunctionDNA-directed DNA polymerase activity
Molecular Functionmetal ion binding
Biological ProcessDNA replication proofreading

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    DNA polymerase III subunit epsilon
  • EC number

Gene names

    • Name
      dnaQ
    • ORF names
      EBS_1348

Organism names

Accessions

  • Primary accession
    S6BD07

Proteomes

Subcellular Location

Interaction

Subunit

DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain, region.

TypeIDPosition(s)Description
Domain7-179Exonuclease
Region180-206Disordered

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    242
  • Mass (Da)
    26,608
  • Last updated
    2013-10-16 v1
  • Checksum
    6F48609ABAAD68E1
MSEAGKRQIVLDTETTGLEPAQGHRIIEIGCVELIDRRLTGNNFHVYLQPDREIDAGAVEVHGITNEFLADKPRFADIAEEFIAYLRGAEVIIHNAPFDVGFIDAEFARLPEGPRMAELCEITDTLVMAREMHPGQRNSLDALCGRYDIDNAHRTKHGALLDAEILADVYLAMTGGQKTLSLEGEEDGESSEGEASGIRRLPADRPPLRVVRASAEELARHEQRLAAIDKASGGKTLWRAEG

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AP012978
EMBL· GenBank· DDBJ
BAN69243.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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